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. 2021 Mar 24;9(3):e002355. doi: 10.1136/jitc-2021-002355

Figure 2.

Figure 2

IFN-γ suppresses signaling through multiple oncogenic growth factor receptors in tumor cells. (A) Western blots of the indicated proteins from MMC cells unstimulated and after IFN-γ treatment with tubulin loading control. Densitometric quantification of the (B) indicated growth factor receptor or (C) signaling molecule after treatment with IFN-γ (blue bars) compared with the untreated control cells (gray bars); n=3 independent experiments, **P<0.01, ***P<0.001, ****P<0.0001. IFN-γ, interferon gamma; IR, insulin receptor; p-IR, phosphorylated IR; IGF-IR, insulin-like growth factor receptor-1; p-IGF-IR, phosphorylated IGF-IR; EGFR, epidermal growth factor receptor; p-EGFR, phosphorylated EGFR; PTEN, phosphatase and tensin homolog; AKT, serine/threonine-protein kinase; p-AKT, phosphorylated AKT; STAT-1, signal transducer and activator of transcription 1; p-STAT-1, phosphorylated STAT-1.