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. 2021 Mar 24;9(3):e002355. doi: 10.1136/jitc-2021-002355

Figure 4.

Figure 4

Vaccine-induced IFN-γ-secreting Th1 sensitize tumors to monoclonal antibody therapy and chemotherapy in vivo, resulting in tumor rejection. (A) Representative western blot and (B) densitometric quantification for phospho-IGF-IR in tumors from mice immunized with adjuvant alone (control) or the IGF-IR epitope vaccine presented as box and whisker plots with Tukey outliers, n=6 tumors/group; *p<0.05. (C) Representative western blot and (D) densitometric quantification for PTEN in tumors from mice immunized with adjuvant alone or the IGF-IR epitope vaccine presented as box and whisker plots with Tukey outliers, n=6 tumors/group; *p<0.05. mean implanted tumor volume (±SEM) from mice immunized with adjuvant alone or the IGF-IR epitope vaccine and treated with 7.16.4 (E) or paclitaxel (F); (E) ****p<0.0001 and *p<0.05 compared with vaccination +7.160.4. (F) ***p<0.001 and ****p<0.0001 compared with vaccination +paclitaxel. IFN-γ, interferon gamma; Th1, T-helper 1; IGF-IR, insulin-like growth factor receptor; p-IGF-IR, phosphorylated IGF-IR; PTEN, phosphatase and tensin homolog.