Figure 2.

Observed and physiologically‐based pharmacokinetic (PBPK) model‐simulated concentrations of resolvin D1 (RvD1). Measurements were performed in (a) plasma and (b) submandibular glands following a dose of 0.1 mg/kg in NOD/ShiLtJ mice with Sjögren’s syndrome (SS) plasma. Black circle, square, and triangle symbols represent data from each individual animal of the observed data, and solid lines represent median RvD1 concentrations from the PBPK model. The shaded region represents the 90% prediction interval for the simulated RvD1 concentrations.