Figure 3.

The physiologically‐based pharmacokinetic concentration‐time model predictions of resolvin D1 (RvD1). Modelling was performed (a) following administration of an oral dose of 0.005 mg per kg in C57BL/6N mice and (b) intraperitoneal dose 0.2 µg/kg in Sprague‐Dawley rats . Solid black lines represent the median predicted concentration; and black triangle symbols represent data from each individual animal of the observed data obtained from the animal study reported by Recchiuti et al. ²⁶ (a) and Krashia et al. ²⁷ (b). The shaded region represents the 90% prediction interval for the simulated RvD1 concentrations.