Table 2.

Physiologic and drug‐specific parameters used for the salivary gland compartment in mice and humans

Parameter	Mice		Humans
	Value	Ref.	Value	Ref.
Physiological parameters
Blood flow rate, mL/minute	3.6 × 10−4	33	160.56	41
Tissue density, g/cm3	1	35	1	35
Fluid recirculation flow rate, mL/minute	2.2 × 10−7	33	N/A	N/A
Fluid circulation flow rate scaling exponent	N/A	N/A	0.67	33
Weight of tissue, mg	60 a	N/A	48,000	40
Organ volume, mL	0.06 b	N/A	48 b	N/A
Surface area, plasma/interstitial, cm2	5.7 × 10−5	33	N/A	N/A
Surface area, plasma/interstitial, proportionality factor, cm−1	N/A	N/A	950	37
Drug‐specific parameters
Partition coefficient, cell/saliva	0.5	25, 37	0.5	25, 37
Partition coefficient, intracellular/plasma	0.04	25, 37	0.04	25, 37

N/A, not applicable.

^aWeight of the salivary gland tissue was obtained from laboratory data.

^bVolume of the salivary gland tissue was calculated using density and mass values.