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AFE in concentration, AUC0‐∞, and Cmax for all RvD1 PBPK models
| Animal model | AFE | ||
|---|---|---|---|
| Concentration | AUC0–∞ | Cmax | |
| NODShiLtJ mice—plasma | 0.52 | 0.42 | 0.22 |
| NODShiLtJ mice—salivary glands | 0.35 | 0.31 | 0.8 |
| C57BL/6N mice—plasma | 0.14 | 0.53 | 0.81 |
| Sprague‐Dawley rats—plasma | 0.69 | 0.7 | 1.7 |
AFE, average fold error; AUC0–∞, area under the concentration‐time curve from zero to infinity; Cmax, peak plasma concentration; PBPK, physiologically‐based pharmacokinetic; RvD1, resolvin D1.
