Table 4.
Summary of CYP‐mediated and transporter‐mediated DDI evaluation by test system
| DDI evaluation type (n) | Evaluation system (n) | |
|---|---|---|
| CYP (n = 40) | CYP induction (15) | Human hepatocytes (13), other microsomes (1), not specified (1) |
| CYP inhibition (19) | Human hepatocytes (5), human microsomes (11) other microsomes (1) multispecies S9 (1), and not specified (1) | |
| CYP substrate (6) | Human microsomes (3), multispecies microsomes (2), multispecies S9 (1) | |
| Transporter (n = 12) | Transporter substrate (2) | Mammalian cell lines (1), Sf9 vesicles (1) |
| Transporter inhibition (2) | Mammalian cell lines and Sf9 vesicles (1) | |
| Transporter substrate and inhibition (8) | Mammalian cell lines (2), mammalian cell lines and Sf9 vesicles (1), not specified (5) |
Multispecies microsome = microsomes from animal species including human microsome, other microsome = non‐human species microsome.
DDI, drug‐drug interaction.