Table 3.
Univariate analysis of SNPs in GSTP1 and ABCB1 and hematological and nonhematological toxicity
| Polymorphism | Anemia | Thrombocytopenia | Neurotoxicity | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
G0‐G2 n (%) |
G3‐G4 n (%) |
P |
G0 n (%) |
G1–G4 n (%) |
P value |
G0‐G1 n (%) |
G2‐G3 n (%) |
P value | |
| GSTP1 c.313A>G | |||||||||
| AA | 39 (79.6) | 10 (20.4) | 0.04 a | 26 (53.1) | 23 (46.9) | < 0.01 b | – | – | – |
| AG | 42 (95.5) | 2 (4.5) | 33 (75.0) | 11 (25.0) | – | – | – | ||
| GG | 18 (94.7) | 1 (5.3) | 17 (89.5) | 2 (10.5) | – | – | – | ||
| Dominant | – | – | – | ||||||
| AA | 39 (79.6) | 10 (20.4) | 0.01 | 26 (53.1) | 23 (46.9) | < 0.01 | – | – | – |
| AG + GG | 60 (95.2) | 3 (4.8) | 50 (79.4) | 12 (20.6) | – | – | – | ||
| Recessive | – | – | – | ||||||
| AA + AG | 81 (87.1) | 12 (12.9) | 0.46 | 59 (63.4) | 34 (36.6) | 0.03 | – | – | – |
| GG | 18 (94.7) | 1 (5.3) | 17 (89.5) | 2 (10.5) | – | – | – | ||
| ABCB1 c.1236C>T | |||||||||
| CC | – | – | – | 26 (68.4) | 12 (31.6) | 0.03 c | – | – | – |
| CT | – | – | – | 43 (75.4) | 14 (24.6) | – | – | – | |
| TT | – | – | – | 7 (41.2) | 10 (58.8) | – | – | – | |
| Dominant | – | – | – | – | – | – | |||
| CC | – | – | – | 26 (60.4) | 12 (31.6) | 1 | – | – | – |
| TT + CT | – | – | – | 50 (67.6) | 24 (32.4) | – | – | – | |
| Recessive | – | – | – | – | – | – | |||
| CC + CT | – | – | – | 69 (72.6) | 26 (27.4) | 0.01 | – | – | – |
| TT | – | – | – | 7 (41.2) | 10 (58.8) | – | – | – | |
| ABCB1 c.3435C>T | |||||||||
| CC | – | – | – | – | – | – | 29 (78.4) | 8 (21.6) | 0.02 d |
| CT | – | – | – | – | – | – | 42 (37.5) | 18 (30.0) | |
| TT | – | – | – | – | – | – | 6 (40.0) | 9 (60.0) | |
| Dominant | – | – | – | – | – | – | |||
| CC | – | – | – | – | – | – | 29 (78.4) | 8 (21.6) | 0.14 |
| TT + CT | – | – | – | – | – | – | 48 (64.0) | 27 (36.0) | |
| Recessive | – | – | – | – | – | – | |||
| CC + CT | – | – | – | – | – | – | 71 (73.2) | 26 (26.8) | 0.01 |
| TT | – | – | – | – | – | – | 6 (40.0) | 9 (60.0) | |
SNP, single‐nucleotide polymorphism.
G0–G4: grade; statistically significant differences are in bold; P values were calculated using the χ2/Fisher exact test.
a
AA vs. AG = 0.02.
b
AA vs. AG = 0.02 AA vs. GG = 0.005.
c
CC vs. TT = 0.05 CT vs. TT = 0.008.
d
CC vs. TT = 0.007 CT vs. TT = 0.03.