Table 4.
Multivariate analysis of anemia and thrombocytopenia with GSTP1 c.313A>G, ABCB1 c.1236C>T, and ABCB1 c.3435C>T polymorphisms
| Polymorphism | Anemia | Thrombocytopenia | Neurotoxicity | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P adj | OR (95% CI) | P adj | OR (95% CI) | P adj | |
| GSTP1 c.313A>G | ||||||
| AA | Reference | Reference | – | – | ||
| AG | 0.16 (0.03–0.84) | 0.03 | 0.32 (0.12–0.82) | 0.01 | – | – |
| GG | 0.18 (0.02–1.64) | 0.13 | 0.11 (0.02–0.59) | < 0.01 | – | – |
| Dominant (AA vs AG + GG) | 0.17 (0.04–0.69) | 0.01 | 0.27(0.12–0.64) | < 0.01 | – | – |
| Recessive (AA + AG vs GG) | 0.34 (0.41–2.89) | 0.32 | 0.18 (0.03–0.85) | 0.03 | – | – |
| ABCB1 c.1236C>T | ||||||
| CC | – | – | Reference | – | – | |
| CT | – | – | 0.77 (0.29–2.07) | 0.61 | – | – |
| TT | – | – | 3.63 (0.98–13.47) | 0.05 | – | – |
| Dominant (CC vs. CT + TT) | – | – | 1.04 (0.44–2.48) | 0.93 | – | – |
| Recessive (CC + CT vs. TT) | – | – | 3.50 (1.12–10.97) | 0.03 | – | – |
| ABCB1 c.3435C>T | ||||||
| CC | – | – | – | – | Reference | |
| CT | – | – | – | – | 1.41 (0.53–3.78) | 0.49 |
| TT | – | – | – | – | 4.54 (1.14–17.91) | 0.03 |
| Dominant (CC vs. CT + TT) | – | – | – | – | 1.79 (0.70–4.60) | 0.22 |
| Recessive (CC + CT vs. TT) | – | – | – | – | 3.61 (1.08–12.01) | 0.03 |
CI, confidence interval; OR, odds ratio.
Odds ratios was adjusted for age, histological subtypes, and International Federation of Gynecology and Obstetrics (FIGO); category bold values indicate statistically significant differences.