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. 2021 Mar 24;6(1):e000682. doi: 10.1136/tsaco-2021-000682

Table 1.

Gene ontology (GO) biologic processes significantly enriched after valproic acid treatment

GO term # proteins (DE/all) P value
Low-density lipoprotein particle clearance 6/9 0.002
ATP hydrolysis coupled cation transmembrane transport 9/19 0.003
SRP-dependent cotranslational protein targeting to membrane 10/24 0.005
Viral transcription 10/24 0.005
Ephrin receptor signaling pathway 7/15 0.009
Membrane organization 31/112 0.01
Regulation of hormone secretion 9/3 0.012
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 9/17 0.018
Response to insulin 11/33 0.021
Generation of precursor metabolites and energy 30/110 0.026
Nuclear-transcribed mRNA catabolic process 10/30 0.028
Mitochondrion organization 20/75 0.03
Retrograde vesicle-mediated transport, Golgi to Endoplasmic Reticulum (ER) 5/11 0.031
Regulation of neurotransmitter transport 10/19 0.033
Regulation of nucleotide metabolic process 6/15 0.036
Gluconeogenesis 7/19 0.037
Antigen processing and presentation 7/19 0.037
Dendrite morphogenesis 7/19 0.037
Monovalent inorganic cation transport 16/58 0.038
Cellular response to hormone stimulus 19/64 0.04
Metal ion transport 20/77 0.04
ATP metabolic process 19/73 0.044
Regulation of dendrite development 5/12 0.046
Regulation of peptidyl-tyrosine phosphorylation 6/16 0.049
Tricarboxylic acid cycle 7/20 0.049

# proteins are the number of proteins differentially expressed in this proteomic data set out of the total number of proteins that contribute to that GO term.

P value represents the corrected p value after Elim pruning.