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. 2021 Mar 23;36(1):819–830. doi: 10.1080/14756366.2021.1901088

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Inhibitory effect of 100 μM bisphosphonate containing compounds on the activity of the human metalloproteases, MMP-9 and MMP-14, and the bacterial metalloproteases TLN, PLN, and ALN. The inhibition experiments were performed by using a fixed concentration of 4 μM of both the MMP-9 and MMP-14 substrate McaPLGL(Dpa)AR-NH₂ and the ALN, PLN and TLN substrate McaRPPGFSAFK(Dnp)-OH. The v_i/v₀ (mean ± sd) were based on 4–6 experiments.