Table 2:
Diagnostic values for MDS-PSP criteria for “probable 4R-tauopathy”, MDS PSP criteria for PSP, and Armstrong criteria for CBD
| 4RT | PSP | CBD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sens. | Spec. | PPV | NPV | Sens. | Spec. | PPV | NPV | Sens. | Spec. | PPV | NPV | ||
| 1. year | MDS PSP criteria for prob. 4RT | 9.6 | 99.4 | 96.0 | 41.5 | 10.8 | 98.1 | 84.0 | 39.2 | 5.5 | 93.7 | 12.0 | 86.2 |
| MDS PSP criteria for PSP | 47.2 | 88.2 | 86.1 | 51.8 | 52.8 | 70.7 | 75.2 | 47.1 | 27.3 | 65.7 | 11.0 | 85.4 | |
| Armstrong criteria for CBD | 0.8 | 100 | 100 | 39.4 | 0.5 | 99.5 | 50.0 | 52.6 | 1.8 | 99.7 | 50.0 | 86.8 | |
| 2. year | MDS PSP criteria for prob. 4RT | 17.2 | 99.4 | 97.7 | 43.6 | 19.5 | 97.2 | 86.4 | 57.2 | 9.1 | 89.0 | 11.4 | 86.4 |
| MDS PSP criteria for PSP | 45.6 | 88.2 | 85.7 | 51.1 | 58.5 | 81.9 | 74.5 | 68.6 | 36.4 | 62.6 | 13.1 | 86.4 | |
| Armstrong criteria for CBD | 2.8 | 100 | 100 | 39.9 | 2.1 | 98.6 | 57.1 | 52.7 | 5.5 | 98.9 | 42.9 | 87.1 | |
| 3. year | MDS PSP criteria for prob. 4RT | 23.6 | 98.1 | 95.2 | 45.3 | 25.6 | 94.4 | 80.7 | 58.5 | 16.4 | 85.1 | 14.5 | 86.8 |
| MDS PSP criteria for PSP | 59.2 | 82.0 | 83.6 | 56.4 | 64.1 | 75.9 | 70.6 | 70.1 | 41.8 | 56.7 | 13.0 | 86.3 | |
| Armstrong criteria for CBD | 3.2 | 100 | 100 | 40.0 | 2.1 | 98.2 | 50.0 | 52.6 | 7.3 | 98.9 | 50.0 | 87.3 | |
| Final record | MDS PSP criteria for prob. 4RT | 58.8 | 88.2 | 88.6 | 58.0 | 65.1 | 82.4 | 76.5 | 72.8 | 36.4 | 58.9 | 12.1 | 85.7 |
| MDS PSP criteria for PSP | 81.2 | 51.6 | 72.2 | 63.9 | 86.2 | 47.7 | 59.8 | 79.2 | 63.6 | 30.9 | 12.5 | 35.3 | |
| Armstrong criteria for CBD | 17.2 | 99.4 | 97.7 | 43.6 | 17.4 | 95.4 | 77.3 | 56.1 | 16.4 | 90.2 | 20.5 | 87.5 | |
Sensitivity (Sens.), specificity (Spec.), positive predictive value (PPV), negative predictive value (NPV) in % for clinical diagnostic criteria when applied to our autopsy cases with 4R-tauopathy (PSP, N=195; CBD, N=55), and non-4R-tauopathy (MSA, N=50; PD, N=51; 4R-tau negative FTLD, N=60) within 1. - 3. year of disease and at final record.