Table 2.
Results of Dynamic light Scattering, expressed as the mean (n=3) ± SD of the monomer radius (nm), % pd of the monomer population, % intensity and % mass of monomer and PDI for each Ab formulation before and after stress
| mAb 1 | mAb 2 | mAb 3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before stress | Shaking | Device 1 | Device 2 | Before stress | Shaking | Device 1 | Device 2 | Before stress | Shaking | Device 1 | Device 2 | |
| radius (nm) |
7.5 ± 0.3 |
7.0 ± 0.3 |
6.7 ± 0.6 |
6.9 ± 0.4 |
5.5 ± 0.6 |
5.0 ± 0.1 |
5.0 ± 0.1 |
4.9 ± 0.0 |
9.3 ± 0.7 |
8.7 ± 0.4 |
9.2 ± 1.3 |
8.8 ± 0.5 |
| % pd |
9 ± 0.0 |
16 ± 0.1 |
30 ± 0.1 |
16 ± 0.1 |
9 ± 0.0 |
6 ± 0.0 |
7 ± 0.0 |
9 ± 0.1 |
15 ± 0.0 |
18 ± 0.1 |
11 ± 0.0 |
11 ± 0.0 |
| % monomer (intensity) |
100.0 ± 0.0 |
99.7 ± 0.0 |
95.8 ± 0.0 |
96.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
99.8 ± 0.0 |
98.5 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
99.8 ± 0.0 |
| % monomer (mass) |
100.0 ± 0.0 |
99.9 ± 0.0 |
99.9 ± 0.0 |
99.9 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
100.0 ± 0.0 |
| PDI |
0.113 ± 0.016 |
0.102 ± 0.004 |
0.214 ± 0.024 |
0.219 ± 0.350 |
0.071 ± 0.010 |
0.070 ± 0.004 |
0.114 ± 0.010 |
0.157 ± 0.029 |
0.119 ± 0.004 |
0.134 ± 0.031 |
0.132 ± 0.012 |
0.162 ± 0.016 |