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. 2021 Mar 25;11(4):1625–1633. doi: 10.1007/s13346-021-00967-w

Table 2.

Results of Dynamic light Scattering, expressed as the mean (n=3) ± SD of the monomer radius (nm), % pd of the monomer population, % intensity and % mass of monomer and PDI for each Ab formulation before and after stress

mAb 1 mAb 2 mAb 3
Before stress Shaking Device 1 Device 2 Before stress Shaking Device 1 Device 2 Before stress Shaking Device 1 Device 2
radius (nm)

7.5

± 0.3

7.0

± 0.3

6.7

± 0.6

6.9

± 0.4

5.5

± 0.6

5.0

± 0.1

5.0

± 0.1

4.9

± 0.0

9.3

± 0.7

8.7

± 0.4

9.2

± 1.3

8.8

± 0.5

% pd

9

± 0.0

16

± 0.1

30

± 0.1

16

± 0.1

9

± 0.0

6

± 0.0

7

± 0.0

9

± 0.1

15

± 0.0

18

± 0.1

11

± 0.0

11

± 0.0

% monomer (intensity)

100.0

± 0.0

99.7

± 0.0

95.8

± 0.0

96.0

± 0.0

100.0

± 0.0

100.0

± 0.0

99.8

± 0.0

98.5

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

99.8

± 0.0

% monomer (mass)

100.0

± 0.0

99.9

± 0.0

99.9

± 0.0

99.9

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

100.0

± 0.0

PDI

0.113

± 0.016

0.102

± 0.004

0.214

± 0.024

0.219

± 0.350

0.071

± 0.010

0.070

± 0.004

0.114

± 0.010

0.157

± 0.029

0.119

± 0.004

0.134

± 0.031

0.132

± 0.012

0.162

± 0.016