Table 2.
Resistance determinants detected in ESBL-EC isolates from humans, chickens and farm/market environment in Abuja - Nigeria, 2019
| Antibiotic classa | Resistance determinants of ESBL-EC isolates (no of isolates)b |
|---|---|
| Aminoglycoside | aadA1 (6), aadA2 (4), aadA5 (3), aac(3)-IIa (4), aac(3)-IId (11), aac(3)-Ib (1), aac(6)-Ib-cr (1), aph(3)-Ia (6), aph(3)-Ib (25), aph(6)-Id (22) |
| β-lactamases | blaTEM-1 (33), blaTEM-20 (1), blaOXA-1 (1), blaOXA-129 (1), blaCTX-M-15 (3), blaCTX-M-65 (1) |
| Colistin | mcr-1.1 (1) |
| Macrolide | mdfA (34), mphA (11), mphB (1) |
| Phenicol | cmlA1 (2), catA1 (4), catA2 (1), catB3 (1), floR (6) |
| Rifampicin | ARR-3 (1) |
| Quinolone | qnrB1 (1), qnrB19 (6), qnrS1 (24), qnrS2 (2), aac(6)-Ib-cr (1) |
| Sulphonamide | sul1 (7), sul2 (30), sul3 (3) |
| Tetracycline | tetA (31), tetB (3) |
| Trimethoprim | dfrA1 (3), dfrA12 (3), dfrA14 (23), dfrA17 (4), dfrA21 (1) |
aDrugs corresponding to each antibiotic class used in our study are as follows: aminoglycosides, streptomycin, gentamicin; beta-lactams, ampicillin, ceftriaxone, cefotaxime, ceftazidime, ceftiofur, cefoxitin, amoxicillin-clavulanic acid, and cefpodoxime; quinolones, nalidixic acid, and ciprofloxacin; phenicols, chloramphenicol; sulfonamides and trimethoprim, trimethoprim-sulfamethoxazole, Sulfisoxazole; tetracyclines, tetracycline; macrolides, azithromycin.
bThe number of isolates carrying each resistance determinant are presented in parentheses