Table 2.
Hazard ratios for NAFLD events by quintiles of serum lipoproteins and LDL/HDL cholesterol ratio
| HR (95%CI) | |||||||
|---|---|---|---|---|---|---|---|
| Multivariable Analysis | Q1 | Q2 | Q3 | Q4 | Q5 | P-trend | |
| HDL cholesterol (mmol/l) | |||||||
| Crude Model | 0.25 (0.19, 0.33) | Ref | 0.92 (0.77, 1.10) | 0.71 (0.58, 0.86) | 0.51 (0.41, 0.63) | 0.32 (0.25, 0.41) | < 0.001 |
| Model I | 0.26 (0.20, 0.33) | Ref | 0.92 (0.77, 1.10) | 0.71 (0.58, 0.87) | 0.51 (0.41, 0.64) | 0.32 (0.25, 0.41) | < 0.001 |
| Model II | 0.59 (0.45, 0.77) | Ref | 1.05 (0.88, 1.26) | 0.95 (0.78, 1.17) | 0.85 (0.68, 1.06) | 0.60 (0.46, 0.79) | < 0.001 |
| Model III | 0.59 (0.44, 0.78) | Ref | 1.04 (0.86, 1.25) | 0.91 (0.74, 1.11) | 0.83 (0.66, 1.04) | 0.61 (0.47, 0.80) | < 0.001 |
| Model IV | 0.57 (0.42, 0.75) | Ref | 0.98 (0.82, 1.18) | 0.84 (0.69, 1.04) | 0.80 (0.64, 1.01) | 0.61 (0.46, 0.79) | < 0.001 |
| LDL cholesterol (mmol/l) | |||||||
| Crude Model | 3.24 (2.70, 3.88) | Ref | 1.12 (0.85, 1.49) | 1.45 (1.12, 1.89) | 1.97 (1.53, 2.52) | 3.37 (2.67, 4.26) | < 0.001 |
| Model I | 3.21 (2.68, 3.85) | Ref | 1.12 (0.85, 1.49) | 1.45 (1.11, 1.88) | 1.96 (1.53, 2.51) | 3.34 (2.64, 4.22) | < 0.001 |
| Model II | 3.18 (2.40, 4.21) | Ref | 1.26 (0.93, 1.69) | 1.48 (1.09, 2.02) | 2.00 (1.45, 2.76) | 3.10 (2.17, 4.41) | < 0.001 |
| Model III | 2.72 (2.03, 3.63) | Ref | 1.25 (0.92, 1.70) | 1.40 (1.02, 1.92) | 1.80 (1.29, 2.50) | 2.65 (1.84, 3.82) | < 0.001 |
| Model IV | 2.60 (1.95, 3.48) | Ref | 1.22 (0.90, 3.48) | 1.37 (0.99, 1.88) | 1.70 (1.22, 2.37) | 2.50 (1.74, 3.60) | < 0.001 |
| LDL/HDL cholesterol ratio | |||||||
| Crude Model | 3.42 (2.93, 3.99) | Ref | 1.92 (1.40, 2.63) | 2.47 (1.82, 3.35) | 3.05 (2.27, 4.10) | 5.35 (4.05, 7.07) | < 0.001 |
| Model I | 3.38 (2.90, 3.95) | Ref | 1.92 (1.40, 2.64) | 2.47 (1.82, 3.35) | 3.05 (2.27, 4.10) | 5.32 (4.02, 7.03) | < 0.001 |
| Model II | 1.72 (1.44, 2.06) | Ref | 1.63 (1.18, 2.24) | 1.89 (1.39, 2.58) | 1.87 (1.38, 2.53) | 2.43 (1.80, 3.28) | < 0.001 |
| Model III | 1.64 (1.37, 1.97) | Ref | 1.70 (1.23, 2.35) | 1.83 (1.34, 2.51) | 1.89 (1.39, 2.56) | 2.41 (1.77, 3.27) | < 0.001 |
| Model IV | 1.66 (1.38, 1.99) | Ref | 1.68 (1.21, 2.33) | 1.78 (1.30, 2.44) | 1.86 (1.36, 2.55) | 2.40 (1.76, 3.27) | < 0.001 |
Crude model adjusted for none; Model I adjusted for gender and age; Model II adjusted for TC, TG and BMI; Model III adjusted for gender, age, ALP, GGT, ALT, AST, ALB, GLB, DBIL, CR, UA, FPG, TC, TG, height, BMI, SBP and DBP; Model IV adjusted for Model III and TP, TB, BUN
Abbreviations: NAFLD nonalcoholic fatty liver disease, CI confidence interval, HR hazard ratios; other abbreviations as in Table 1