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. 2021 Mar 25;21:321. doi: 10.1186/s12885-021-08056-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The antitumor efficacy of RGD4C-p21Ras-scFv in vitro. (a and b) Cell migration was measured with a scratch test after SW480 cells were cocultured with 20 μM RGD4C-scFv, RGD4C-linker-scFv or the anti-p21Ras scFv for 0 h, 24 h, and 48 h. The migration of SW480 cells was inhibited in the RGD4C-scFv and RGD4C-linker-scFv groups compared with the anti-p21Ras scFv and PBS control groups. (c and d) The migration of SW480 cells was inhibited in the RGD4C-scFv and RGD4C-scFv+CQ groups compared with RGD4C-EGFP and PBS groups. Moreover, the migration inhibition effect of RGD4C-scFv+CQ groups was higher than RGD4C-scFv group. (e-h) There were no difference the migration of CACO-2 and CCD841 cells in the RGD4C-scFv and RGD4C-scFv+CQ groups compared with RGD4C-EGFP and PBS groups