Table 1.
Previously known condition-associated CDR3s in the list of DA enriched CDR3s identified by the method (using randomization test)
| Dataset | known condition-associated CDR3s in all samples (*likely CD4, CD8) | Feature space | Known condition-associated CDR3s in DA enriched (likely CD4, CD8) | Permutation test p value (CD4, CD8) |
|---|---|---|---|---|
| CD PBMC | 56 (20, 36) | nt 4-mer | 14 (9, 3) | p = 0.0 (0.0, 0.09) |
| CD PBMC | 56 (20, 36) | aa 3-mer | 10 (7, 2) | p = 0.0 (0.0, 0.33) |
| CD GUT | 50 (23, 24) | nt 4-mer | 3 (0, 3) | p = 0.48 (1, 0.05) |
| CD GUT | 50 (23, 24) | aa 3-mer | 5 (1, 4) | p = 0.13 (0.85, 0.02) |
| YFV PBMC | 12,092 | nt 4-mer | 697 | p = 0.0 |
| Twin YFV PBMC | 5730 | nt 4-mer | 2058 | p = 0.0 |
*Previously reported CD associated CDR3s are assumed likely CD4 and CD8 based on their reported CD4 and CD8 status in the papers they were reported. For some such information was not available
p values show non-significant results