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. Author manuscript; available in PMC: 2021 May 14.
Published in final edited form as: Semin Diagn Pathol. 2020 Jun 5;38(3):222–231. doi: 10.1053/j.semdp.2020.05.005

Fig. 5.

Fig. 5.

SMARCA4-deficient undifferentiated malignancies. A: SMARCA4-deficient undifferentiated thoracic sarcoma arising in the lung of an adult male, comprised of malignant epithelioid cells growing in sheets with a high degree of mitotic activity (A, arrow), areas of tumor necrosis (A, inset), and occasionally prominent eosinophilic nucleoli (A, inset) with SMARCA4 loss in tumor cells (B). C: Targeted NGS identified a heterozygous splice-site mutation inactivating SMARCA4 (c.3169–2A>T, arrow). D: SMARCA4-deficient undifferentiated sarcoma arising in the base of the tongue of an adult female, comprised of plump tumor cells with epithelioid and pleomorphic cytomorphology, irregularly shaped large nuclei, and moderate amounts of eosinophilic cytoplasm, growing in sheets, with frequent mitoses (D, arrow) and apoptotic bodies. E: Expression of SMARCA4 was lost in tumor cells. The tumor cells expressed strong and diffuse SOX2 (F).