Table 3.
Logistic regression predicting the likelihood of EHT based on the metabolites/metabolite ratios selected for panel 1 and panel 2
| Panel 1a | Metabolite | B | Exp(B) | 95% CI for Exp(B) | Sig. | |
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| C18:1 | 0.79 | 2.203 | 0.963 | 5.042 | .061 | |
| C18:2 | 0.504 | 1.655 | 0.747 | 3.666 | .214 | |
| Ornithine | 0.312 | 1.366 | 0.669 | 2.788 | .392 | |
| Spermidine | 0.769 | 2.157 | 1.339 | 3.477 | .002 | |
| Constant | 7.095 | 1205.524 | .027 | |||
| Panel 1b | metabolite ratio | |||||
| Citrulline/Ornithine | 0.296 | 1.344 | 0.619 | 2.918 | .454 | |
| Ornithine/Arginine | 1.196 | 3.306 | 1.674 | 6.529 | .001 | |
| Spermidine/Putrescine | 0.631 | 1.88 | 1.192 | 2.967 | .007 | |
| Constant | 2.238 | 9.378 | <.001 | |||
| Panel 2a | metabolite | |||||
| C3-DC (C4-OH) | 0.733 | 2.082 | 0.883 | 4.908 | .094 | |
| C9* | –0.967 | 0.38 | 0.172 | 0.839 | .017 | |
| C16* | –0.807 | 0.446 | 0.109 | 1.824 | .261 | |
| C16:1* | 2.292 | 9.891 | 1.636 | 59.807 | .013 | |
| C18:1* | 0.083 | 1.087 | 0.267 | 4.416 | .908 | |
| C18:2* | 0.198 | 1.219 | 0.487 | 3.052 | .672 | |
| Arginine* | –1.174 | 0.309 | 0.118 | 0.81 | .017 | |
| Aspartate* | 0.674 | 1.961 | 0.867 | 4.439 | .106 | |
| Glutamate | 0.068 | 1.071 | 0.611 | 1.876 | .811 | |
| Ornithine* | 0.572 | 1.772 | 0.695 | 4.517 | .231 | |
| Spermidine* | 0.698 | 2.009 | 1.15 | 3.51 | .014 | |
| lysoPC a C20:4* | –0.089 | 0.915 | 0.358 | 2.337 | .853 | |
| PC aa C38:6 | –0.731 | 0.481 | 0.065 | 3.594 | .476 | |
| PC aa C40:6 | 0.667 | 1.949 | 0.296 | 12.839 | .488 | |
| PC aa C42:1 | 0.927 | 2.527 | 0.889 | 7.178 | .082 | |
| Constant | 16.52 | 14947591.2 | .021 | |||
| Panel 2b | metabolite ratio | B | Exp(B) | 95% CI for Exp(B) | Sig. | |
| lower | upper | |||||
| Citrulline/Arginine* | –16.119 | 9.99 × 10–08 | 1.42 × 10–16 | 70.154 | .121 | |
| Citrulline/Ornithine* | 16.508 | 14770678.1 | 0.023 | 9.6091 × 1015 | .111 | |
| CPT-I ratio* | 0.675 | 1.963 | 0.941 | 4.095 | .072 | |
| Ornithine/Arginine* | 17.429 | 37084306.7 | 0.056 | 2.439 × 1016 | .092 | |
| Spermidine/Putrescine* | 0.621 | 1.86 | 1.171 | 2.955 | .009 | |
| Total DMA/Arginine* | –0.236 | 0.79 | 0.336 | 1.854 | .588 | |
| Tyrosine/Phenylalanine* | –1.334 | 0.263 | 0.073 | 0.953 | .042 | |
| Constant | 6.017 | 410.15 | .09 |
Abbreviations: B, B coefficient; Exp(B), odds ratio of the independent variable; CI, confidence interval; sig., significant. For abbreviations/nomenclature of the variable please refer to Table 2. Statistically significant values (P < .05) are presented in bold. Metabolites/metabolite ratios found using both approaches (classical [top 15 metabolites] and machine-learning approach) are marked with an asterisk (*).