Table 5.

Phenotype comparison between girls with CPP with and without MKRN3 mutations

	MKRN3 CPP (n = 45)	Idiopathic CPP (n = 156)	P
Thelarche (years)	6.3 ± 1.2	6.0 ± 1.7	.38
Pubarche (years)	7.1 ± 1.2	6.8 ± 1.9	.24
First evaluation (years)	7.2 ± 1.1	8.4 ± 2.0	.001
Diagnostic delay (years)	0.8 ± 0.8	2.4 ± 2.1	<.001
BAA (years)	2.1 ± 1.6	2.6 ± 1.3	.08
Height SDS	1.2 ± 1.2	1.7 ± 1.1	.04
BMI SDS	0.9 ± 0.9	0.8 ± 0.9	.90
Basal LH (IU/L)	1.7 ± 1.8	1.3 ± 1.4	.22
Basal FSH (IU/L)	4.9 ± 2.3	3.8 ± 2.7	.03
Estradiol (ng/dL)	29.8 ± 20.8	30.1 ± 30.3	.95
LH peak (IU/L)	20.2 ± 14.4	17.3 ± 16.6	.45
FSH peak (IU/L)	16.9 ± 4.6	14.2 ± 10.2	.18

Data are shown as mean ± standard deviation. Diagnostic delay (years) was defined as the difference between the age at first evaluation and the age at fist pubertal signs.

Abbreviations: BAA, bone age advance; CPP, central precocious puberty; SDS, standard deviation score; LH, luteinizing hormone; FSH, follicle-stimulating hormone.