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. 2020 Dec 31;106(4):e1062–e1073. doi: 10.1210/clinem/dgaa912

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — microRNA expression levels. Differences in microRNA expression levels between individuals with normal glucose tolerance (CON) and patients with type 2 diabetes (T2D) are depicted as a volcano plot with statistically significant different microRNAs marked as A, green circles showing a tendency for upregulation in patients with type 2 diabetes. Further stratification of the top 15 statistically different microRNAs is presented in a heat map for individuals with normal glucose tolerance without osteoarthritis (CON-OA), with osteoarthritis (CON+OA), patients with type 2 diabetes without osteoarthritis (T2D-OA), and with osteoarthritis (T2D+OA). Differences in microRNA expression levels between individuals with osteoarthritis (+OA) and patients without osteoarthritis (-OA) are depicted as volcano plot with statistically significant different microRNAs marked as B, green circles showing a tendency for downregulation in individuals with normal glucose tolerance without osteoarthritis. Further stratification of the top 15 statistically different microRNAs is presented in a heat map for individuals with normal glucose tolerance without osteoarthritis (CON-OA), with osteoarthritis (CON+OA), patients with type 2 diabetes without osteoarthritis (T2D-OA), and with osteoarthritis (T2D+OA). Green shades depict upregulation, whereas yellow shades depict downregulation.