Table 3.

Risk of Pituitary Adenoma in NHS, NHSII, and HPFS by Measures of Body Habitus, Stratified by Sex

		Women (n = 325)			Men (n = 62)
		Casesa	MV HRbc	95%CI	Casesa	MV HRb	95%CI
BMI	<25	185	Ref.		15	Ref.
	25–29.9	82	1.45	1.11–1.89	40	2.25	1.24–4.09
	≥30	58	1.77	1.33–2.34	6	1.45	0.56–3.78
	Per 5 kg/m2	325	1.27	1.17–1.37	61	1.22	0.90–1.66
Maximum BMI	<25	130	Ref.		12	Ref.
	25–29.9	103	1.55	1.19–2.03	42	2.46	1.29–4.70
	≥30	92	1.77	1.34–2.35	7	1.56	0.60–4.01
	Per 5 kg/m2	325	1.24	1.15–1.34	61	1.17	0.86–1.59
Waist circumference	Quintile 1	18	Ref.		1	Ref.
	Quintile 2	26	0.96	0.50–1.83	5	4.69	0.55–40.24
	Quintile 3	22	1.16	0.61–2.20	11	13.18	1.69–102.62
	Quintile 4	27	1.43	0.78–2.62	15	13.20	1.73–100.62
	Quintile 5	38	2.06	1.17–33.64	10	9.89	1.26–77.78
	Per inch	131	1.06	1.03–1.09	42	1.09	1.01–1.17
Baseline BMId	<25	212	Ref.		16	Ref.
	25–29.9	71	1.31	1.00–1.72	41	2.49	1.39–4.44
	≥30	42	1.49	1.07–2.08	2	0.66	0.15–2.88
	Per 5 kg/m2	325	1.22	1.10–1.34	59	1.08	0.75–1.56
Height	Quintile 1	56	Ref.		8	Ref.
	Quintile 2	63	1.09	0.76–1.58	15	1.28	0.54–3.04
	Quintile 3	67	1.25	0.88–1.79	13	1.46	.60–3.55
	Quintile 4	70	1.24	0.87–1.77	15	1.02	0.43–2.43
	Quintile 5	69	1.42	1.00–2.02	11	1.19	0.47–2.98
	Per inch	325	1.05	1.00–1.09	62	1.05	0.95–1.15
Young adult BMIe	<25	248	Ref.		47	Ref.
	25–29.9	30	1.40	0.96–2.05	11	0.78	0.40–1.51
	≥30	15	2.65	1.56–4.49	0	-
	Per 5 kg/m2	293	1.32	1.14–1.52	58	0.81	0.51–1.30
Age 20 somatotype	1–2	85	Ref.		12	Ref.
	3–5	159	0.97	0.74–1.27	17	0.59	0.28–1.25
	6–9	17	2.30	1.35–3.91	1	0.55	0.07–4.31
Age 10 somatotype	1–2	131	Ref.		18	Ref.
	3–5	119	1.04	0.81–1.33	9	0.75	0.34–1.68
	6–9	9	1.18	0.60–2.32	3	0.87	0.25–3.01
Age 5 somatotype	1–2	149	Ref.		19	Ref.
	3–5	106	1.05	0.82–1.35	8	0.74	0.32–1.69
	6–9	3	0.71	0.22–2.22	3	1.59	0.46–5.47
Birthweight	<7 lbs.	58	Ref.		1	Ref.
	7–8.5 lbs.	88	1.27	0.91–1.76	7	3.75	0.46–30.65
	>8.5 lbs.	30	1.51	0.97–2.35	4	4.24	0.47–38.31
Smoking status	Never	192	Ref.		22	Ref.
	Past	85	0.94	0.72–1.23	37	1.81	1.06–3.09
	Current	34	0.77	0.53–1.14	3	0.81	0.24–2.71

Abbreviations: BMI, body mass index; HPFS, Health Professionals Follow-Up Study; HR, hazard ratio; MV, multivariable; NHS, Nurses’ Health Study; NHSII, Nurses’ Health Study II.

^aCases may not sum to total due to missing values.

^bAdjusted for age and smoking status (never vs. past vs. current).

^cCalculated by fixed effect meta-analysis of NHS and NHSII.

^dBaseline is 1986 in HPFS, 1976 in NHS, and 1989 in NHSII.

^eAge 18 in NHS and NHSII, age 21 in HPFS.