. 2021 Jan 8;106(4):1591–1602. doi: 10.1210/clinem/dgaa987

Table 4.

Risk of Pituitary Adenoma in HPFS, NHS, and NHSII by Measures of Body Habitus, Lagged Analyses

		14-Year Lag			12-Year Lag			10-Year Lag			8-Year Lag
		Cases^a	MV HR^bc	95%CI	Cases^a	MV HR^bc	95%CI	Cases^a	MV HR^bc	95%CI	Cases^a	MV HR^bc	95%CI
BMI	<25	61	Ref.		68	Ref.		82	Ref.		83	Ref.
	25–29.9	40	1.37	0.91–2.06	43	1.23	0.82–1.85	56	1.40	0.98–2.00	64	1.53	1.08–2.17
	≥30	28	1.81	1.14–2.86	33	1.73	1.13–2.64	39	1.70	1.15–2.51	47	1.91	1.32–2.78
	Per 5 kg/m²	129	1.27	1.10–1.46	144	1.22	1.06–1.40	177	1.22	1.07–1.38	194	1.27	1.13–1.42
Maximum BMI	<25	52	Ref.		49	Ref.		79	Ref.		77	Ref.
	25–29.9	46	1.70	1.13–2.55	49	1.42	0.96–2.11	60	1.50	1.05–2.13	66	1.48	1.04–2.10
	≥30	31	2.09	1.32–3.29	36	1.88	1.23–2.89	38	1.74	1.18–2.58	51	1.82	1.26–2.63
	Per 5 kg/m²	129	1.25	1.09–1.44	144	1.22	1.07–1.39	177	1.20	1.06–1.36	194	1.24	1.11–1.38
		6-Year Lag			4-Year Lag			2-Year Lag			No Lag
		Cases^a	MV HR^bc	95%CI	Cases^a	MV HR^bc	95%CI	Cases^a	MV HR^bc	95%CI	Cases^a	MV HR^bc	95%CI
BMI	<25	91	Ref.		106	Ref.		132	Ref.		200	Ref.
	25–29.9	77	1.61	1.15–2.24	98	1.75	1.31–2.35	111	1.66	1.27–2.18	122	1.56	1.22–1.98
	≥30	55	1.94	1.37–2.74	60	1.80	1.30–2.50	71	1.80	1.33–2.43	64	1.74	1.33–2.28
	Per 5 kg/m²	223	1.27	1.14–1.40	264	1.25	1.14–1.38	314	1.25	1.14–1.36	386	1.26	1.17–1.37
Maximum BMI	<25	82	Ref.		97	Ref.		119	Ref.		142	Ref.
	25–29.9	80	1.61	1.15–2.24	98	1.64	1.21–2.22	115	1.66	1.26–2.20	145	1.66	1.30–2.13
	≥30	61	1.93	1.37–2.73	69	1.81	1.31–2.50	80	1.81	1.34–2.44	99	1.76	1.34–2.30
	Per 5 kg/m²	223	1.26	1.14–1.39	264	1.24	1.13–1.36	314	1.24	1.14–1.35	386	1.24	1.15–1.33

Abbreviations: BMI, body mass index; HPFS, Health Professionals Follow-Up Study; MV, multivariable; NHS, Nurses’ Health Study; NHSII, Nurses’ Health Study II.

^aCases may not sum to total due to missing values.

^bAdjusted for age, cohort (which adjusts for sex), smoking status (never vs. past vs. current).

^cCalculated by fixed effect meta-analysis of all 3 cohorts.