Table 2.
Sequential immunofluorescence in a subset of samples
| HLA class I | STAT 1 | PKR | VP1 | |
|---|---|---|---|---|
| Chronic GD 1 | Positive | Negative | Negative | Negative |
| Chronic GD 2 | Positive | Positive | Positive | Positive |
| Chronic GD 3 | Positive | Negative | Positive | Positive |
| Chronic GD 4 | Negative | Negative | Positive | Positive |
| Chronic GD 5 | Positive | Negative | Positive | Positive |
| Chronic GD 6 | Positive | Positive | Positive | Positive |
| Chronic GD 7 | Negative | Negative | Negative | Negative |
| Chronic GD 8 | Negative | Negative | Positive | Positive |
| Chronic GD 9 | Positive | Positive | Positive | Positive |
| New GD 1 | Positive | Positive | Positive | Positive |
| New GD 2 | Positive | Positive | Positive | Positive |
| New GD 3 | Positive | Positive | Positive | Positive |
| New GD 4 | Positive | Positive | Positive | Positive |
| Control 1 | Positive | Positive | Positive | Positive |
| Control 2 | Positive | Positive | Negative | Negative |
| Control 3 | Negative | Negative | Negative | Negative |
| Control 4 | Negative | Negative | Negative | Negative |
Seventeen samples were stained sequentially with immunofluorescence for HLA class I, STAT1, PKR, and VP1. The table shows that the majority of the GD samples were both HLA class I and STAT1 positive (shown in bold). All new GD samples stained positively for all proteins studied.
Abbreviations: GD, Graves disease; HLA, human leukocyte antigen; PKR, protein kinase R; STAT1, signal transducer and activator of transcription 1; VP1, enteroviral capsid protein 1.