Table 2. Incidence rates (95% CI) and hazard ratios (95% CI) for the association of GlycA with incident atrial fibrillation: The multi-ethnic study of atherosclerosis (2000–2015).
| GlycA in μmol/L | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Per 1 SD (62 μmol/L) increment |
|---|---|---|---|---|---|
| [Median (IQR)] | [314 (294–327)] | [359 (348–368)] | [397 (386–407)] | [452 (435–480)] | |
| N | 1,670 | 1,661 | 1,630 | 1,641 | 6,602 |
| Cases | 213 | 226 | 228 | 202 | 869 |
| Incidence rates† | 11.2 (9.8–12.8) | 12.0 (10.5–13.7) | 12.4 (10.9–14.1) | 11.2 (9.8–12.9) | 11.7 (11.0–12.5) |
| Hazard Ratios* | |||||
| Model 1 | 1 (reference) | 1.03 (0.85–1.24) | 1.11 (0.92–1.34) | 1.13 (0.92–1.38) | 1.07 (0.99–1.15) |
| Model 2 | 1 (reference) | 0.98 (0.81–1.19) | 1.00 (0.83–1.22) | 0.98 (0.79–1.21) | 1.02 (0.94–1.10) |
| Model 3 | 1 (reference) | 0.96 (0.79–1.17) | 0.98 (0.81–1.20) | 0.95 (0.77–1.18) | 1.01 (0.93–1.09) |
| Model 4 | 1 (reference) | 0.95 (0.78–1.16) | 0.95 (0.77–1.17) | 0.86 (0.67–1.10) | 0.97 (0.88–1.06) |
Abbreviation: CI, confidence interval; SD, standard deviation.
† Crude incidence rates reported are per 1000 person-years.
*Model 1: Adjusted for age, sex, and race/ethnicity and MESA site.
*Model 2: Model 1 plus education, health insurance, BMI, smoking status, pack-years of smoking, and physical activity.
*Model 3: Model 2 plus systolic blood pressure, use of antihypertensive medication, total cholesterol, HDL-cholesterol, use of lipid-lowering medication, diabetes and eGFR.
*Model 4: Model 3 plus ln(CRP), ln(IL-6) and ln(Fibrinogen).
‡ P value = 0.65, 0.05 and 0.23 for interaction by age, sex and race/ethnicity using quartiles of GlycA as the exposure variable. Results remained similar and not statistically significant when stratified by sex.