Table 3. Incidence rates (95% CI) and hazard ratios (95% CI) for the association of CRP, IL-6 and fibrinogen with incident atrial fibrillation: The multi-ethnic study of atherosclerosis (2000–2015).
| CRP in mg/L | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Per 1 SD |
| [Median (IQR)] | [0.5 (0.3–0.7)] | [1.3 (1.0–1.5)] | [2.8 (2.3–3.4)] | [7.3 (5.4–11.5)] | (5.2 mg/L) increment |
| N | 1,617 | 1,614 | 1,604 | 1,611 | 6,446 |
| Cases | 195 | 230 | 216 | 207 | 848 |
| Incidence rates† | 10.5 (9.1–12.1) | 12.6 (11.1–14.4) | 12.1 (10.6–13.8) | 11.5 (10.1–13.2) | 11.7 (11.0–12.5) |
| Hazard Ratios* | 1 (reference) | 1.00 (0.82–1.22) | 0.94 (0.76–1.16) | 0.98 (0.76–1.26) | 0.99 (0.91–1.08) |
| IL-6 in pg/mL | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Per 1 SD |
| [Median (IQR)] | [0.6 (0.5–0.7)] | [1.0 (0.9–1.1)] | [1.5 (1.3–1.7)] | [2.7 (2.2–3.6)] | (1.2 pg/mL) increment |
| N | 1,612 | 1,611 | 1,612 | 1,611 | 6,446 |
| Cases | 140 | 188 | 256 | 264 | 848 |
| Incidence rates† | 7.2 (6.1–8.5) | 10.1 (8.7–11.6) | 14.5 (12.8–16.4) | 15.7 (13.9–17.7) | 11.7 (11.0–12.5) |
| Hazard Ratios* | 1 (reference) | 1.05 (0.84–1.32) | 1.33 (1.06–1.67) | 1.42 (1.10–1.82) | 1.12 (1.05–1.19) |
| Fibrinogen in mg/dL | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Per 1 SD |
| [Median (IQR)] | [269 (250–284)] | [317 (307–327)] | [362 (349–373)] | [428 (405–463)] | (72 mg/dL) increment |
| N | 1,643 | 1,583 | 1,638 | 1,582 | 6,446 |
| Cases | 177 | 230 | 223 | 227 | 868 |
| Incidence rates† | 9.3 (8.0–10.8) | 12.9 (11.3–14.7) | 12.1 (10.6–13.8) | 12.6 (11.0–14.4) | 11.7 (11.0–12.5) |
| Hazard Ratios* | 1 (reference) | 1.20 (0.98–1.47) | 0.96 (0.78–1.19) | 0.94 (0.74–1.20) | 0.99 (0.91–1.08) |
Abbreviation: CI, confidence interval; SD, standard deviation.
Sample size = 6,446 after excluding participants with missing data on IL-6 and Fibrinogen.
† Crude incidence rates reported are per 1000 person-years.
*Model: Adjusted for age, sex, race/ethnicity, MESA site, education, health insurance, BMI, smoking status, pack-years of smoking, physical activity, systolic blood pressure, use of antihypertensive medication, total cholesterol, HDL-cholesterol, use of lipid-lowering medication, diabetes and eGFR and log transformed CRP, IL-6, fibrinogen, and including GlycA. Interactions by age, race and sex were not significant for CRP, IL-6 and Fibrinogen using quartiles of each inflammatory biomarker as the exposure variable.