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. Author manuscript; available in PMC: 2021 Jul 22.
Published in final edited form as: Science. 2021 Jan 22;371(6527):eabc3393. doi: 10.1126/science.abc3393

Fig. 5. Location of H3K36 at the PRC2-nucleosomal DNA interface.

Fig. 5.

Close-up view of the location of histone H3K36 and its interactions with nucleosomal DNA and PRC2. Bulky residues in PRC2 close to H3K36 are shown in stick representation, with the orange sphere indicating the potential space available for alternative conformations of the H3K36 side chain. On the right is the cryo-EM density (contour level: 0.024) with the atomic model shown, illustrating the distances between the H3K36 terminal amine group and the nearest bulky residues.