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. 2021 Feb 17;13(5):6752–6764. doi: 10.18632/aging.202532

Figure 7.

Figure 7

The scheme illustrates the mechanism of action of miR-23a in the nerve injury and pain initiation. Sensory neuron-derived EVs-encapsulated miR-23a exacerbates neuropathic pain and promotes M1 polarization of macrophages in peripheral nerve injury by inhibiting A20 and activating the NF-κB signaling.