Table 2. Clinicopathological characteristics of breast cancer patients and associations with breast cancer prognosis.
| Characteristics | N=2647 | Stage I | Stage II | Overall survival | Disease-free survival | |||
| (%) | (N=1297, %) | (N=1350, %) | HR (95% CI) | P | HR (95% CI) | P | ||
| TNM stage | ||||||||
| 0-IIa | 1593 (67.7) | 772 (65.5) | 821 (69.9) | 1 (ref) | <0.001 | 1 (ref) | <0.001 | |
| IIb-IV | 761 (32.3) | 407 (34.5) | 354 (30.1) | 3.493 (2.672-4.568) | 2.776 (2.203-3.498) | |||
| Tumor size | ||||||||
| ≤2.5cm | 1483 (67.8) | 683 (65.2) | 800 (70.2) | 1 (ref) | <0.001 | 1 (ref) | <0.001 | |
| >2.5cm | 704 (32.2) | 364 (34.8) | 340 (29.8) | 2.092 (1.591-2.750) | 1.694 (1.291-2.221) | |||
| Histopathologic classification | ||||||||
| non-IDC | 789 (29.9) | 449.(34.7) | 340 (25.2) | 1 (ref) | <0.001 | 1 (ref) | <0.001 | |
| IDC | 1853 (70.1) | 846 (65.3) | 1007 (74.8) | 1.815 (1.324-2.487) | 1.629 (1.275-2.082) | |||
| Grade | ||||||||
| I | 187 (10.0) | 74 (8.1) | 113 (11.7) | 1 (ref) | 0.015 | 1 (ref) | 0.004 | |
| II | 1390 (74.0) | 693 (76.0) | 697 (72.2) | 1.814 (0.954-3.449) | 2.903 (1487-5.668) | |||
| III | 301 (16.0) | 145 (15.9) | 156 (16.1) | 2.593 (1.294-5.198) | 2.934 (1.421-6.056) | |||
| Lymph node | ||||||||
| Negative | 2029 (78.2) | 983 (77.2) | 1046 (79.1) | 1 (ref) | <0.001 | 1 (ref) | <0.001 | |
| Positive | 567 (21.8) | 290 (22.8) | 277 (20.9) | 4.488 (3.466-5.813) | 3.672 (2.934-4.597) | |||
| ER | ||||||||
| Negative | 1028 (40.0) | 576 (44.9) | 452 (35.1) | 1 (ref) | <0.001 | 1 (ref) | 0.002 | |
| Positive | 1542 (60.0) | 707 (55.1) | 835 (64.9) | 0.589 (0.456-0.761) | 0.701 (0.561-0.877) | |||
| PR | ||||||||
| Negative | 1187 (46.2) | 563 (43.9) | 624 (48.5) | 1 (ref) | <0.001 | 1 (ref) | <0.001 | |
| Positive | 1383 (53.8) | 720 (56.1) | 662 (51.5) | 0.519 (0.399-0.675) | 0.599 (0.478-0.751) | |||
| HER2 | ||||||||
| Negative | 1824 (76.7) | 910 (79.3) | 914 (74.2) | 1 (ref) | 0.003 | 1 (ref) | 0.018 | |
| Positive | 555 (23.3) | 237 (20.7) | 318 (25.8) | 1.544 (1.157-2.062) | 1.365 (1.055-1.767) | |||
ER, estrogen receptor; PR, progestogen receptor; HER2, human epidermal growth factor receptor 2; non-IDC, non-invasive ductal carcinoma; IDC, invasive ductal carcinoma; HR, hazard ratio; CI, confidence interval.