Table 5. Association between rs10878441 and breast cancer overall survival.
| SNP | N | Univariate | Multivariate | |||
| HR (95% CI) | P | HR (95% CI) | P# | |||
| rs10878441 (A/C) (Stage I) | ||||||
| AA | 476 | 1 (ref) | 1 (ref) | |||
| AC | 610 | 1.00 (0.58-1.70) | 0.986 | 1.09 (0.52-2.29) | 0.811 | |
| CC | 211 | 2.63 (1.51-4.58) | 0.001 | 2.46 (1.07-5.68) | 0.035 | |
| Additive model | 1297 | 1.64 (1.20-2.23) | 0.002 | 1.56 (0.99-1.45) | 0.053 | |
| Dominant model | 1297 | 1.40 (0.87-2.26) | 0.170 | 1.38 (0.70-2.74) | 0.353 | |
| Recessive model | 1297 | 2.63 (1.65-4.21) | <0.001 | 2.33 (1.16-4.68) | 0.018 | |
| rs10878441 (A/C) (Stage II) | ||||||
| AA | 498 | 1 (ref) | 1 (ref) | |||
| AC | 614 | 1.35 (0.95-1.92) | 0.100 | 1.69 (0.99-2.88) | 0.055 | |
| CC | 186 | 1.27 (0.77-2.07) | 0.349 | 2.21 (1.11-4.42) | 0.024 | |
| Additive model | 1298 | 1.16 (0.93-1.46) | 0.188 | 1.51 (1.08-2.10) | 0.015 | |
| Dominant model | 1298 | 1.33 (0.95-1.86) | 0.100 | 1.80 (1.08-2.99) | 0.024 | |
| Recessive model | 1298 | 1.07 (0.69-1.67) | 0.767 | 1.63 (0.89-2.97) | 0.111 | |
| rs10878441 (A/C) (Combined) | ||||||
| AA | 974 | 1 (ref) | 1 (ref) | |||
| AC | 1224 | 1.19 (0.89-1.60) | 0.250 | 1.40 (0.91-2.16) | 0.122 | |
| CC | 397 | 1.69 (1.18-2.42) | 0.004 | 2.19 (1.30-3.70) | 0.003 | |
| Additive model | 2595 | 1.29 (1.07-1.54) | 0.007 | 1.47 (1.13-1.92) | 0.004 | |
| Dominant model | 2695 | 1.31 (0.99-1.72) | 0.056 | 1.57 (1.05-2.36) | 0.028 | |
| Recessive model | 2695 | 1.53 (1.12-2.10) | 0.008 | 1.79 (1.14-2.79) | 0.011 | |
SNP, single-nucleotide polymorphism; HR, hazard ratio; CI, confidence interval.
#Adjusted for age at diagnosis, education, occupation, age at menarche, number of live births, breastfeeding duration, abortion, menopause, TNM stage, tumor size, histopathologic classification, grade, lymph node, ER, PR, and HER2.