Table 2. Baseline characteristics and genetic variation according to P2Y12 platelet adenosine 5′-diphosphate receptor G52T polymorphism in elderly patients.
| GG | GT | TT | p-value | |
| (N=598) | (N=187) | (N=26) | ||
| Male sex | 312 (52.2%) | 110 (58.8%) | 11 (42.3%) | 0.145 |
| Age (years) | 79.2±3.7 | 79.0±3.4 | 78.6±3.4 | 0.591 |
| Body-mass index (kg/m2) | 23.8±3.5 | 23.5±3.1 | 23.6±2.3 | 0.424 |
| Current smoker | 62 (10.4%) | 22 (11.8%) | 3 (11.5%) | 0.857 |
| Hypertension | 424 (70.9%) | 150 (80.2%) | 20 (76.9%) | 0.039 |
| Diabetes mellitus | 197 (32.9%) | 71 (38.0%) | 10 (38.5%) | 0.406 |
| Hypercholesterolemia | 177 (29.6%) | 66 (35.3%) | 9 (34.6%) | 0.314 |
| Previous MI | 33 (5.5%) | 15 (8.0%) | 3 (11.5%) | 0.250 |
| Previous PCI | 92 (15.4%) | 32 (17.1%) | 2 (7.7%) | 0.453 |
| Previous CABG | 7 (1.2%) | 3 (1.6%) | 1 (3.8%) | 0.486 |
| Previous CVA | 61 (10.2%) | 27 (14.4%) | 3 (11.5%) | 0.277 |
| Congestive heart failure | 36 (6.0%) | 16 (8.6%) | 0 (0.0%) | 0.186 |
| Chronic kidney disease | 40 (6.7%) | 9 (4.8%) | 4 (15.4%) | 0.119 |
| Familial history of CAD | 16 (2.7%) | 11 (5.9%) | 1 (3.8%) | 0.110 |
| Anemia | 283 (47.3%) | 88 (47.1%) | 11 (42.3%) | 0.882 |
| Presentation with ACS | 335 (56.0%) | 104 (55.6%) | 13 (50.0%) | 0.832 |
| PRECISE-DAPT score | 26.1 ± 9.7 | 25.3 ± 8.7 | 26.0 ± 9.2 | 0.564 |
| - High risk | 276 (46.2%) | 89 (47.6%) | 13 (50.0%) | 0.541 |
| CYP2C19 | 0.268 | |||
| - NM | 224 (37.5%) | 68 (36.4%) | 6 (23.1%) | |
| - IM | 295 (49.3%) | 85 (45.5%) | 16 (61.5%) | |
| - PM | 79 (13.2%) | 34 (18.2%) | 4 (15.4%) |
Values are expressed as the number of patients (%) or mean (SD). ACS, acute coronary syndrome; CABG, coronary artery bypass graft; CAD, coronary artery disease; CVA, cerebrovascular accident; IM, intermediate metabolizer; MI, myocardial infarction; NM, normal metabolizer; PCI, percutaneous coronary intervention; PM, poor metabolizer.