Table 2. COVID-19 related symptoms, biology, treatment, and clinical outcomes of centenarians vs residents aged 65-99 years.

Characteristics	Patient 65 to 99 years old (n=309)		Patient 100 and over (n=12)		p-value
	n	%	n	%
Asymptomatic	61	19.7	2	16.7	1.000
Symptoms
Dyspnea	115	37.2	4	33.3	1.000
Dry cough	84	27.2	2	16.7	0.526
Fever	131	42.4	6	50.0	0.768
Hypothermia	15	4.9	1	8.3	0.465
Asthenia	159	51.5	6	50.0	1.000
Anorexia	66	21.4	5	41.7	0.147
Gastrointestinal signs	56	18.1	2	16.7	1.000
Ear, Nose, Throat (ENT)	25	8.1	2	16.7	0.267
Headache	7	2.3	-	-
Myalgia	9	2.9	-	-
Delirium	42	13.6	2	16.7	0.673
Worsening of depression	17	5.5	3	25.0	0.032
Altered consciousness	18	5.8	1	8.3	0.525
Fall	26	8.4	-	-
Biological characteristics*
Anemia	90	29.1	6	50.0	0.194
Neutropenia	16a	6.6	1α	10.0	0.508
Lymphopenia	69a	28.4	4α	40.0	0.480
Thrombopenia	21a	8.6	1α	10.0	0.604
C-reactive protein>10mg/L	163b	71.8	7β	77.8	1.000
Treatment
Antibiotics**	201	65.0	10	83.3	0.231
Azithromycin	231	74.8	10	83.3	0.737
Hydroxychloroquine	99	32.0	1	8.3	0.113
Hydration	150	48.5	9	75.0	0.084
Preventive anticoagulation	85	27.5	4	33.3	0.743
Oxygen therapy	116	37.5	5	41.7	0.769
Drug-drug interactions	139	45.0	5	41.7	1.000
Adverse event	33	10.7	1	8.3	1.000
Hospitalization	76	24.6	1	8.3	0.306
In COVID unit	74	23.9	1	8.3	0.307
Home hospitalization	111	35.9	4	33.3	1.000
Palliative care	42	13.6	4	33.3	0.77
Death	66	21.3	6	50.0	0.031
Death due to COVID	45	84.9	6	100.0	0.583
Place of death
COVID unit	27	8.7	1	8.3	0.296
Nursing home	39	12.6	5	41.7	0.062

*Anemia was defined as hemoglobin level <120 g/L; Neutropenia as neutrophils level <1.5 G/L; Lymphopenia as lymphocytes level <1.0 G/L; Thrombopenia was defined as platelets level < 150 G/L.

**Antibiotics used were penicillin, ceftriaxone, macrolides (other than azithromycin) and tetracycline.

^an=66 values were missing; ^αn=2 values were missing; b 82 missing values; β 3 missing values.