Table 1. Microbiota that changed with age and are reversed by caloric restriction.

Microbiota	C57BL/6 Mice		B6D3F1 Mice
	Cecum	Colon	Cecum	Colon
Bacteroides acidifaciens	↑	↑	↑	NC
Mucispirillum schaedleri	↓	↓	NC	NC
Genus Bacteroides	↑	↑	↑	↑
Genus Coprococcus	NC	↑	NC	NC
Genus Oscillospira	↓	↓	↓	NC
Genus Parabacteroides	↓	↓	↓	↓
Genus Ruminococcus	↓	↓	↓	↓
Family Christensenellaceae	NC	↑	ND	ND
Family F16	↑	↑	↑	↑
Family Mogibacteriaceae	↓	ND	↓	↓
Family Rikenellaceae	↑	↑	↑	↑
Family S24-7	↑	↑	↑	↑
Order Bacteroidales	↑	ND	ND	ND
Order Clostridiales	NC	↓	NC	↑
Order RF39	↓	NC	NC	NC

The data are taken from Supplementary Tables 1–3 in the supplement. For the C57BL/6 mice: ↑indicates microbes that showed a decrease in abundance with age that was significantly increased by CR in old mice and ↓ indicates microbes that increased in abundance with age and was significantly reduced by CR in old mice. In B6D2F1 mice: ↑indicates microbes that showed significant increase in abundance by CR in old mice and ↓ indicates microbes that showed significant decrease in abundance by CR in old mice. NC = No Significant Change. ND = Not Detected.