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. 2021 Feb 26;13(5):7284–7299. doi: 10.18632/aging.202583

Table 1. Characteristics of included studies.

Author year Glycolysis marker Country Ethnicity Tumor location Follow-up (months) Sample size Gender (M/F) Detection method TNM stage Cut-off value Outcome HR [95% CI] Study design NOS score
Ayala 2010[14] GLUT1 Brazil Caucasian OSCC 64.9(0.03-157.6) 142 112/30 TMA IHC I-IV ≥10% OS 2.07[1.23-3.46] P 7
Baschnagel 2015[35] GLUT1
HK2		 America Caucasian HNSCC 35(1-93) 97 NA IHC I-IV GLUT1:Score=3(0-3)
HK2:Score≥1(0-3)		 DFS 2.13[0.86-5.28]
1.01[0.50-2.05]		 P 7
Brockton 2011[15] GLUT1 Canada Caucasian HNSCC NA 47 37/10 TMA IHC II-IV NA OS 1.21[0.22-6.65] P 6
Chang 2017[16] GLUT4 China Asian HNSCC 190 90 81/9 IHC I-IV Score≥2(0-3) OS
RFS		 3.31[1.28-8.55]
3.76[1.76-8.03]		 P 8
Choi 2007[31] GLUT1 Korea Asian OSCC 4.10-117.13 60 40/20 IHC I-IV ≥60% OS
DFS		 1.70[0.63-4.62]
1.62[0.78-3.34]		 P 7
Curry 2013[36] MCT4 America Caucasian OSCC 45(2.8-94.9) 42 27/15 IHC I-IV ≥25% DFS 10.36[2.56-41.94] P 7
Deron 2011[38] GLUT4 Belgium Caucasian TTSCC 49(1-123) 71 62/9 IHC I-IV Score≥2(0-15) OS
DFS		 1.08[0.41-2.89]
0.78[0.32-1.92]		 P 7
Eckert 2008[32] GLUT1 Germany Caucasian OSCC 60 42 33/9 IHC I-IV Score≥6(0-12) OS 5.05[2.05-12.45] P 7
Eckert 2011[40] GLUT1 Germany Caucasian OSCC 44.3 82 60/22 IHC I-IV Score≥9(0-12) DSS 1.76[0.78-3.93] P 7
Grimm 2014[37] GLUT1 Germany Caucasian OSCC 52.26(46.21-58.31) 161 122/39 IHC I-IV Score≥1(0-9) DFS 0.29[0.04-2.32] P 8
Han 2012[17] GLUT1 Korea Asian OSCC 40(9-113) 33 20/13 IHC II >10% DFS
OS		 1.16[0.14-9.61]
12.46[0.67-231.55]		 P 5
Jonathan 2006[41] GLUT1 Netherlands Caucasian HNSCC 61.2 58 43/15 IHC I-IV Score≥2(0-3) DMFS 4.67[0.33-65.13] P 8
Krupar 2017[19] GLUT1 Germany Caucasian HNSCC 60 73 67/7 IHC II-IV NA OS 1.75[1.01-3.04] P 6
Kunkel 2003[33] GLUT1 Germany Caucasian OSCC 74(1-172) 118 88/30 IHC I-IV ≥50% OS 2.65[1.24-5.65] P 7
Kunkel 2007[34] GLUT1 Germany Caucasian OSCC 62(25-106) 40 33/7 IHC I-IV NA OS 5.12[1.12-23.40] P 6
Oliver 2004[39] GLUT1 UK Caucasian OSCC 60-72 54 36/18 IHC NA Score≥2(0-3) RFS 2.66[0.56-12.78] P 6
Swartz 2016[18] GLUT1 Netherlands Caucasian Oropharyngeal SCC 35(15.8-67) 274 190/84 TMA IHC I-IV >6% OS 1.50[1.05-2.15] P 7
Sweeny 2012[20] MCT4 America Caucasian cSCC of the head and neck NA 50 43/7 IF III-IV >50% DSS 2.42[0.48-12.33] P 7
Wang 2015[21] PKM2 China Asian OSCC 51.4(3-78) 111 60/61 IHC I-IV Score≥4(0-12) OS
DFS		 3.12[1.66-5.85]
2.53[1.01-6.37]		 P 7
Wang 2017-1[22] HK2 China Asian OSCC 71.3 137 89/48 IHC I-IV Score>4(0-9) OS 2.15[1.07-4.31] P 7
Wang 2017-2[23] PKM2 China Asian OSCC 67 137 89/48 IHC I-IV Score>4(0-9) OS 2.15[1.02-4.52] P 7
Wu 2013[24] GLUT1 China Asian LSCC 42.6(13-181) 49 43/6 IHC I-IV >10% OS 3.46[0.73-16.25] P 7
Xiao 2014[25] HK2 America Caucasian NPC 69.72 41 38/9 IHC I-III NA OS 2.05[1.01-4.16] P 4
Yuan 2014[26] PKM2 China Asian OSCC 46.8(2-80) 63 37/26 IHC I-IV Score≥4(0-12) OS 6.05[1.52-24.07] P 7
Zhang 2016[27] HK2 China Asian NPC 52.49(3.75-93.63) 140 107/33 IHC I-IV Score>3(0-12) OS
DMFS		 1.72[0.46-6.38]
1.26[0.36-4.45]		 P 7
RFS 3.71[0.04-349.71]
Zhou 2017[28] GLUT1 China Asian NPC 36 63 41/22 IHC I-IV >2 OS 1.72[0.88-3.34] P 7
Zhu 2014[29] MCT4 China Asian OSCC NA 99 59/40 IHC I-IV Score≥6(0-7) OS
DFS		 3.64[1.60-8.29]
3.42[1.51-7.78]		 P 7
Zuo 2016[30] GLUT1 China Asian LSCC NA 57 47/10 IHC I-IV NA OS 1.97[0.12-33.19] P 6

M/F: male/female; cut-off value: value that distinguishes high and low expression of glycolysis markers; HR: hazard ratio; CI: confidence interval; TMA: tissue microarray; IHC: Immunohistochemistry; P: prospective; NA: not available; OSCC: oral squamous cell carcinoma; LSCC: laryngeal squamous cell carcinoma; SCC: squamous cell carcinoma; cSCC: cutaneous squamous cell carcinoma; IF: Immunofluorescence staining; NPC: nasopharyngeal carcinoma; TTSCC: squamous cell carcinoma of the tonsil and mobile tongue.