Table 2. Group difference in brain metabolism and grey matter volume by using whole-brain confirmatory analysis (FWE corrected for multiple comparisons across the entire volume).
| ROI | Brain regions | Cluster size | T value | Peak MNI coordinates | ||
| X | Y | Z | ||||
| FDG-PET | ||||||
| AD < NC | ||||||
| DMN | ||||||
| L Angular | 1596 | 13.12 | -42 | -62 | 50 | |
| R Angular | 1339 | 12.07 | 52 | -62 | 46 | |
| PCC | 2034 | 7.72 | 0 | -54 | 36 | |
|
DMN (GMV-controlled) |
||||||
| L Angular | 95 | 8.72 | -42 | -62 | 50 | |
| R Angular | 57 | 7.79 | 50 | -60 | 42 | |
| PCC | 168 | 7.73 | 0 | -52 | 36 | |
| VBM | ||||||
| AD < NC | ||||||
| R PHG | 471 | 10.93 | 11 | -36 | -2 | |
| R Amygdala | 210 | 10.01 | 21 | 0 | -14 | |
| L PHG | 373 | 9.17 | -15 | 0 | -17 | |
| R MTG | 264 | 9.15 | 57 | -55 | 19 | |
| L MTG | 189 | 9.07 | -54 | -18 | -11 | |
| PCC | 154 | 8.17 | 9 | -35 | 42 | |
| L Angular | 136 | 9.01 | -35 | -64 | 45 | |
| R Angular | 67 | 7.92 | 33 | -66 | 45 | |
Voxel level P < 0.001 after FWE correction. Abbreviations: PCC, posterior cingulate cortex; PHG, parahippocampal gyrus; MTG, middle temporal gyrus; FDG-PET, Fluoro-2-deoxy-D-glucose positron emission tomography; DMN, default mode network; GMV, gray matter volume; VBM, voxel-based morphometry; AD, Alzheimer’s disease; NC: normal controls.