Table 3. Loci with multiple independent mutations in patients 1 and 2.
Genes with multiple mutations in the corresponding CDSs of the longitudinal isolates from patient 1 (P1bm2009 –P1Bm2015) and patient 2 (P2Bm2011a, b), see Tables I and K in S1 Tables respectively. These adaptive mutations have not been reported in the B. multivorans literature (Table L in S1 Tables).
| Gene Product (locus) | Patient | Function | Previously identified |
|---|---|---|---|
| PurB (0592) | 1 | Adenylosuccinate lyase | no |
| Hypothetical (1166) | 1 | Fusaric acid resistance protein family | no |
| Glycosyltransferase (2375) | 1 | LPS modification | no |
| AlgP (2966) | 1 | Alginate production | no |
| LysR (3936) | 1 | Regulation of transcription | no |
| CheA (4025) | 1 | Chemotaxis | no |
| FimV (4911) | 1 | Type IV motility, pilus assembly | no |
| TetR (7680) | 2 | TetR family transcriptional regulator | no |
| Amidase (20235) | 2 | Amidase protein | no |