Table 4. Loci undergoing parallel evolution in patients 1–4.
List of 30 locus with mutations (SNPs) in at least three patients (see also Table I in S1 Tables). We separated the isolates from 2011 and the isolate from 2018 in patient 2 as we regard them as two separate acquisition events.
| Mutated locus present? | |||||||
|---|---|---|---|---|---|---|---|
| P1 | P2_2011 | P2_2018 | P3 | P4 | Locus | Gene | Function |
| 0129 | MFS transporter | ||||||
| 1045 | plsX | phosphate acyltransferase PlsX | |||||
| 1134 | astD | succinylglutamate-semialdehyde dehydrogenase | |||||
| 1149 | nodulation protein | ||||||
| 1201 | DUF2242 domain-containing protein | ||||||
| 1600 | TetR family transcriptional regulator | ||||||
| 1764 | protease modulator HflC | ||||||
| 1788 | DNA polymerase III subunit gamma/tau | ||||||
| 2211 | DNA alkylation response protein | ||||||
| 2519 | ATPase | ||||||
| 2580 | amino acid permease | ||||||
| 2840 | potassium transporter | ||||||
| 2966 | alginate biosynthesis protein AlgP | ||||||
| 3147 | hypothetical protein | ||||||
| 3210 | rsmB | 16S rRNA (cytosine(967)-C(5))-methyltransferase | |||||
| 3483 | MFS transporter | ||||||
| 3702 | GNAT family N-acetyltransferase | ||||||
| 3720 | hemagglutinin | ||||||
| 4338 | molybdopterin-dependent oxidoreductase | ||||||
| 4442 | CBS domain-containing protein | ||||||
| 4911 | pilus assembly protein FimV | ||||||
| 5135 | hypothetical protein | ||||||
| 5336 | sensor histidine kinase | ||||||
| 5391 | helix-turn-helix transcriptional regulator | ||||||
| 5441 | type II toxin-antitoxin system RelE/ParE | ||||||
| 5799 | ABC transporter substrate-binding protein | ||||||
| 6056 | ctaD | cytochrome c oxidase subunit I | |||||
| 6124 | BON domain-containing protein | ||||||
| 6144 | DUF1269 domain-containing protein | ||||||
| 6156 | LysR family transcriptional regulator | ||||||