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. 2021 Mar 25;16(3):e0248241. doi: 10.1371/journal.pone.0248241

Fig 8. Expression of lysosomal markers in cultures of human proximal tubule cells.

Fig 8

Human RTE cells were treated with 5.5mM, 7.5mM, 11mM and 16mM glucose with or without 100μM sorbinil for three serial passages. RT- qPCR analysis of (A) CLCN7; (B) LIPA; (C) IGF2R; (D) MCOLN1; (E) NEU1; (F) NPC2; (G) RRAGD and (H) SQSTM1. ****; ***; **; * indicates significant differences in gene expression level between hRTE cells treated with glucose only and glucose with sorbinil at p-value of ≤ 0.0001; ≤ 0.001; ≤ 0.01; ≤ 0.05 respectively.