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. 2021 Mar 25;7:18. doi: 10.1038/s41421-021-00250-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative flow plots for the expressions of OX40 and CD137 within CD3⁺CD4⁺ T cells of cultured PBMCs stimulated with SARS-CoV-2 peptide library in different subjects. b SARS-CoV-2-specific CD4⁺ T cells measured as percentage of AIM⁺ (OX40⁺CD137⁺) after stimulation of PBMCs with peptide pools encompassing S, M, and N. Each symbol represents an individual throughout. RS, individuals recovered from COVID-19 with symptoms (n = 20); RA, individuals recovered from asymptomatic (n = 13); HC, healthy controls (n = 10). Data were background subtracted against DMSO negative control, and if the value is greater than 0.1%, the individual is considered as response to peptide library stimulation. The number of response individuals is shown in brackets, and the dotted line indicated the cut-off for positive responder. The comparisons between two groups were performed by using unpaired, two-sided Mann–Whitney U test. S, spike; M, membrane; N, nucleocapsid.