Table 5.
Adjusted IRRs (95% CI, p-value) for total sex-chromosome disomy by Quartiles of DAP Metabolite Concentrations (Exposure 1) by 3PBA Concentrations Quartile (Exposure 2) of men seeking infertility evaluation (n= 159).
| 3PBA Quartilea | DAP Quartileb–f | Total Disomy |
||||
|---|---|---|---|---|---|---|
| DMP IRR (95% CI) | DMTP IRR (95% CI) | DMDTP IRR(95% CI) | DEP IRR (95% CI) | DETP IRR (95% CI) | ||
| Q1 | Q1 | 1 | 1 | 1 | 1 | 1 |
| Q2 | 0.75 (0.68, 0.82) | 1.29 (1.18, 1.41) | 1.46 (1.33, 1.61) | 1.33 (1.23, 1.45) | 1.04 (0.94, 1.15) | |
| Q3 | 0.43 (0.33, 0.58) | 1.08 (0.97, 1.19) | 1.03 (0.87, 1.23) | 1.24 (1.13, 1.37) | 2.00 (1.83, 2.19) | |
| Q4 | 0.70 (0.64, 0.77) | 1.13 (0.97, 1.30) | 1.31 (1.19, 1.44) | 1.03 (0.94, 1.13) | 0.96 (0.87, 1.07) | |
| Q2 | Q1 | 1 | 1 | 1 | 1 | 1 |
| Q2 | 0.69 (0.64, 0.75) | 1.05 (0.89, 1.24) | 1.36 (1.11, 1.67) | 1.16 (1.00, 1.33) | 0.39 (0.34, 0.44) | |
| Q3 | 0.67 (0.60, 0.74) | 0.76 (0.66, 0.88) | 0.66 (0.53, 0.82) | 1.07 (0.93, 1.23) | 2.31 (2.02, 2.64) | |
| Q4 | 0.67 (0.61, 0.74) | 1.31 (1.09, 1.57) | 1.09 (1.00, 1.19) | 0.62 (0.53, 0.71) | 0.76 (0.69, 0.84) | |
| Q3 | Q1 | 1 | 1 | 1 | 1 | 1 |
| Q2 | 1.13 (1.06, 1.21) | 1.75 (1.48, 2.06) | 1.96 (1.59, 2.40) | 1.68 (1.48, 1.91) | 0.60 (0.53, 0.68) | |
| Q3 | 1.09 (1.02, 1.16) | 0.95 (0.83, 1.07) | 1.07 (0.88, 1.30) | 0.95 (0.84, 1.09) | 1.89 (1.65, 2.16) | |
| Q4 | 0.98 (0.89, 1.07) | 1.26 (1.06, 1.49) | 1.17 (1.08, 1.26) | 0.92 (0.80, 1.06) | 0.87 (0.80, 0.95) | |
| Q4 | Q1 | 1 | 1 | 1 | 1 | 1 |
| Q2 | 0.53 (0.48, 0.59) | 1.12 (0.96, 1.32) | 1.67 (1.36, 2.05) | 1.27 (1.11, 1.46) | 0.53 (0.46, 0.61) | |
| Q3 | 0.83 (0.76, 0.91) | 0.94 (0.83, 1.08) | 0.87 (0.71, 1.06) | 1.24 (1.07, 1.43) | 1.28 (1.08, 1.52) | |
| Q4 | 0.92 (0.84, 1.01) | 0.72 (0.61, 0.86) | 0.95 (0.83, 1.07) | 0.57 (0.49, 0.67) | 0.84 (0.76, 0.93) | |
| Interaction p-valueg | 0.0015 | < 0.0001 | 0.0022 | < 0.0001 | < 0.0001 | |
3PBA Exposure Quartiles: Q1 = X ≤ LOD (n = 33), Q2 = 0.10 < X ≤ 0.61 ng/mL (n = 46), Q3 = 0.61 < X ≤ 0.83 ng/mL (n = 39), Q4 = X > 0.83 ng/mL (n = 41).
DMP Exposure Quartiles: Q1 = X ≤ LOD (n = 68), Q2 = 0.60 < X≤ 7.95 ng/mL (n = 30), Q3 = 7.95 < X ≤ 13.39 ng/mL (n = 30), Q4 = X > 13.39 ng/mL (n = 31).
DMTP Exposure Quartiles: Q1 = X ≤ LOD (n = 30), Q2 = 0.20 < X ≤ 2.21 ng/mL (n = 43), Q3 = 2.21 < X ≤ 6.47 ng/mL (n = 42), Q4 = X > 6.47 ng/mL (n = 44).
DMDTP Exposure Quartiles: Q1 = X ≤ LOD (n = 69), Q2 = 0.10 < X ≤ 0.73 ng/mL (n = 30), Q3 =0.73 < X ≤ 1.86 ng/mL (n = 30), Q4 = X > 1.86 ng/mL (n = 30).
DEP Exposure Quartiles: Q1 = X ≤ LOD (n = 58), Q2 = 0.20 < X ≤ 1.46 ng/mL (n = 34), Q3 = 1.46 < X ≤ 3.96 ng/mL (n = 33), Q4 = X > 3.96 ng/mL (n = 34).
DETP Exposure Quartiles: Q1 = X ≤ LOD (n = 45), Q2 = 0.10 < X ≤ 0.62 ng/mL (n = 39), Q3 = 0.62 < X ≤ 1.51 ng/mL (n = 37), Q4 = X > 1.51 ng/mL (n = 38).
P-value of the interaction between DAP metabolites and 3PBA in adjusted models. IRRs were adjusted for specific gravity, age, race, BMI, smoking, sperm total concentration, motility, and morphology.