Table 4.

Differential metabolic pathway between groups A and C.

Pathway name	P	Impact	Down#	Up#
Valine, leucine, and isoleucine biosynthesis	<0.001	0.75	Alpha-Ketoisovaleric acid; ketoleucine; L-leucine; L-threonine; L-valine	—
Arginine biosynthesis	<0.001	0.31	L-Glutamine; urea	Citrulline; L-aspartic acid; L-glutamic acid
Cysteine and methionine metabolism	<0.001	0.24	L-Alpha-aminobutyric acid; L-cysteine; L-cystine; L-methionine; pyruvic acid	Homocysteine
Histidine metabolism	0.00183	0.33	1-Methylhistidine; L-histidine	L-Aspartic acid; L-glutamic acid
Alanine, aspartate, and glutamate metabolism	0.00283	0.48	L-Glutamine; pyruvic acid	L-Asparagine; L-aspartic acid; L-glutamic acid
Pantothenate and CoA biosynthesis	0.0036	0.17	Alpha-Ketoisovaleric acid; L-cysteine; L-valine	L-Aspartic acid
D-Glutamine and D-glutamate metabolism	10.0114	0.67	L-Glutamine	L-Glutamic acid
Nitrogen metabolism	0.0167	0.25	L-Glutamine	L-Glutamic acid
Glyoxylate and dicarboxylate metabolism	0.0214	0.08	L-Glutamine; pyruvic acid	Glycolic acid; L-glutamic acid
Glycine, serine, and threonine metabolism	0.0264	0.05	Dimethylglycine; L-cysteine; L-threonine; pyruvic acid	—
Beta-Alanine metabolism	0.0351	0.05	L-Histidine	L-Aspartic acid; spermidine
Arginine and proline metabolism	0.0418	0.10	L-Proline; pyruvic acid	L-Glutamic acid; spermidine
Valine, leucine, and isoleucine degradation	0.0492	0.08	Alpha-Ketoisovaleric acid; ketoleucine; L-leucine; L-valine	—

^#Compared with group C.