Figure 7.

In vivo antitumor efficacy of DHE in U87 tumor xenograft model. Body weights (A) and tumor volumes (B) were recorded every 2 days during the experiment. All mice were euthanized on day 30. (C) The implanted tumors were excised and weighed, and representative tumor photographs of each group were shown. (D) The expression of COX-2, p-p65 and p-IKKβ in implanted tumors was detected by immunohistochemical staining. Representative images of each group were shown. The results are represented as means ± SD (n = 6). (*P<0.05, **P<0.01 and ***P<0.001 as compared with the control group).