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. 2021 Mar 1;11(3):668–690.

Figure 1.

Figure 1

Migration, invasion, and spheroid formation in epithelial ovarian carcinoma cells with ovarian cancer stromal progenitor cells (OCSPCs). (A upper panel) Migration and (A middle panel) invasiveness of SKOV3 or SKOV3-green fluorescent protein (GFP) cells/mesenchymal-like OCSPCs (msc-OCSPCs) compared with SKOV3 or SKOV3-GFP cells/epithelial-like OCSPCs (epi-OCSPCs) and normal ovarian stromal progenitor cells, which were derived from benign ascites. OCSPCs were derived from malignant ascites. (A lower panel) Spheroid formation from SKOV3 cells or SKOV3-GFP cells cocultured with mesenchymal-like OCSPCs (SKOV3/msc-OCSPCs) compared with spheroid formation from SKOV3 cells or SKOV3-GFP cells cocultured with epi-OCSPCs cells (SKOV3/epi-OCSPCs) for 7 or 14 days. (B right) Collagen alpha-3 (VI; COL6A3) expression in OCSPCs following the shRNA knockdown of COL6A3 RNA. m: msc-OCSPCs; m-v: msc-OCSPCs/mockCOL6A3; m22-26: msc-OCSPCs/shCOL6A3. (B left) Invasiveness of SKOV3 cocultured with msc-OCSPCs or msc-OCSPCs/shCOL6A3 cells for 1-3 days.