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. 2021 Mar 1;11(3):668–690.

Figure 9.

Figure 9

Molecular profile changes in epithelial ovarian cancer with collagen alpha-3 (IV; COL6A3) and mesenchymal-like (msc)-ovarian cancer stromal progenitor cell (OCSPC)-derived spheroids treated with LEE011 or COL6A3 knockdown (A) Expression of p-Rb, CDK4, and CDK6 in ES2 and ES2TR with COL6A3 and msc-OCSPC-derived spheroids, compared with their expression in ES2 and ES2TR. (B) Expression of DNA methyltransferase, Rb, p-Rb, CDK1, 4, 6, E-cadherin, and vimentin in ES2 spheroids, ES2TR spheroids, and msc-OCSPCs (pt’s msc) compared with their expression in these cell lines with COL6A3 knockdown (shCOL6A3). (C and D) The molecular profile changes in ES2 spheroids and ES2TR spheroids treated with 0, 2, or 5 μM LEE011. (E) Invasiveness of 1 × 104 ES2, ES2 spheroids, ES2TR, and ES2TR spheroids treated with 30 μM TZD or 1 or 2 μM LEE011 for 3 days.