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. 2021 Mar 1;11(3):668–690.

Figure 10.

Figure 10

LEE011 inhibits epithelial ovarian cancer spheroids and tumor growth. (A) Changes in cell growth in ovarian cancer stromal progenitor cells and (B) SKOV3 cells treated with 0, 2, or 5 μM LEE011. (C, D) The size and numbers of spheroids in (C) ES2 spheroids and ES2 spheroids/shCOL6A3 or (D) ES2TR spheroids and ES2TR spheroids/shCOL6A3. (E) Tumor size and (F) weight changes following subcutaneous injection of mice with ES2 spheroids, (G) ES2TR spheroids alone, or (H) ES2TR spheroids treated with LEE011.