Table 1.
Top 97 differentially methylated CpG sites between GS=6 and GS≥8 patients
| CpG ID | β value | P value | Chromosome | Position | Gene | CpG Location | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| GS=6 | GS≥8 | ||||||
| cg00111102 | 0.9175 | 0.9328 | 1.73E-05 | 20 | 60509975 | CDH4 | Body-shore |
| cg00216361 | 0.0491 | 0.0543 | 1.96E-05 | 3 | 115342527 | GAP43 | 1st Exon-open sea |
| cg00419564 | 0.0223 | 0.0266 | 4.21E-07 | 1 | 153508860 | S100A6 | TSS200-shore |
| cg00567696 | 0.0492 | 0.0564 | 2.37E-06 | 6 | 46097521 | ENPP4 | TSS200-shore |
| cg00619978 | 0.5270 | 0.5650 | 4.13E-06 | 5 | 180046052 | FLT4 | Body-island |
| cg00843795 | 0.6578 | 0.7677 | 1.32E-05 | 7 | 105163736 | PUS7 | TSS1500-shore |
| cg00850868 | 0.6365 | 0.6548 | 9.03E-09 | 10 | 64437920 | IGR | NA |
| cg01071346 | 0.0294 | 0.0335 | 5.61E-06 | 1 | 2480431 | IGR | chr1:2477563-2478363 |
| cg01077623 | 0.7255 | 0.7055 | 2.16E-05 | 7 | 55757733 | FKBP9L | TSS1500-open sea |
| cg01466348 | 0.9389 | 0.9245 | 5.40E-07 | 2 | 161503843 | IGR | NA |
| cg01890546 | 0.9143 | 0.9227 | 1.64E-06 | 7 | 884588 | UNC84A | Body-shelf |
| cg02005490 | 0.9271 | 0.9150 | 6.24E-06 | 5 | 1959850 | IGR | NA |
| cg02048674 | 0.0437 | 0.0505 | 2.24E-06 | 19 | 49991517 | RPL13AP5 | Body-island |
| cg02383160 | 0.0280 | 0.0331 | 1.23E-07 | 11 | 62496393 | TTC9C | 1st Exon-shore |
| cg02895995 | 0.0641 | 0.0741 | 4.94E-08 | 19 | 7554069 | PEX11G | TSS200-shore |
| cg03014008 | 0.5970 | 0.6156 | 1.93E-07 | 20 | 57463767 | GNAS | 3’ UTR-island |
| cg03354554 | 0.2366 | 0.2169 | 2.08E-05 | 11 | 9781412 | IGR | chr11:9779592-9780470 |
| cg03414732 | 0.0713 | 0.0597 | 3.06E-09 | 18 | 32870301 | ZNF271 | Body-island |
| cg04208114 | 0.0454 | 0.0554 | 4.16E-08 | 1 | 59012469 | OMA1 | TSS200-island |
| cg04250904 | 0.6706 | 0.6485 | 2.25E-07 | 19 | 12623422 | ZNF709 | 5’ UTR-shore |
| cg04442328 | 0.1526 | 0.1675 | 1.34E-05 | 3 | 185304136 | SENP2 | 1st Exon-island |
| cg04913913 | 0.1189 | 0.1070 | 7.40E-07 | 6 | 31126599 | CCHCR1 | TSS1500-shore |
| cg05176964 | 0.9753 | 0.9701 | 3.67E-06 | 22 | 42910177 | RRP7A | Body-island |
| cg06295548 | 0.8495 | 0.8741 | 3.28E-08 | 4 | 146296778 | IGR | NA |
| cg06434972 | 0.0371 | 0.0426 | 3.48E-07 | 7 | 44122219 | POLM | TSS200-island |
| cg06834240 | 0.1333 | 0.1507 | 4.07E-08 | 16 | 79632625 | MAF | 3’ UTR-island |
| cg07374247 | 0.0157 | 0.0187 | 3.00E-08 | 6 | 27860935 | HIST1H2AM | 1st Exon-shore |
| cg07872947 | 0.9402 | 0.9481 | 1.47E-06 | 2 | 1732172 | PXDN | Body-open sea |
| cg08005992 | 0.1080 | 0.1219 | 7.13E-06 | 11 | 31832959 | PAX6 | TSS200-island |
| cg08907257 | 0.8877 | 0.8974 | 1.34E-05 | 16 | 2223188 | TRAF7 | Body-shelf |
| cg09618381 | 0.8791 | 0.8566 | 6.12E-07 | 6 | 150379479 | IGR | chr6:150378838-150379048 |
| cg09910998 | 0.5714 | 0.5810 | 1.18E-06 | 7 | 94285942 | SGCE | TSS1500-island |
| cg10149161 | 0.0831 | 0.0680 | 3.18E-10 | 11 | 64578067 | MEN1 | TSS200-island |
| cg10438391 | 0.2942 | 0.2522 | 2.42E-05 | 8 | 144631915 | IGR | chr8:144631767-144631971 |
| cg10446143 | 0.0558 | 0.0626 | 2.16E-05 | 21 | 44394730 | PKNOX1 | 5’ UTR-island |
| cg10632144 | 0.9276 | 0.8967 | 1.27E-05 | 13 | 50252564 | EBPL | Body-open sea |
| cg10797195 | 0.0457 | 0.0514 | 4.70E-06 | 1 | 45805338 | MUTYH | 5’ UTR-shore |
| cg10919522 | 0.2547 | 0.2330 | 1.84E-05 | 14 | 74227441 | C14orf43 | 5’ UTR-shore |
| cg11214243 | 0.0373 | 0.0424 | 2.36E-07 | 11 | 65405388 | SIPA1 | TSS200-shelf |
| cg11678250 | 0.4900 | 0.4546 | 3.31E-06 | 7 | 136362483 | IGR | NA |
| cg11956953 | 0.0881 | 0.0726 | 1.85E-05 | 17 | 27347092 | IGR | chr17:27346853-27347222 |
| cg12791243 | 0.0682 | 0.0609 | 1.01E-06 | 4 | 79698201 | BMP2K | Body-shore |
| cg13038108 | 0.0267 | 0.0317 | 4.34E-07 | 4 | 39461155 | LIAS | Body-shore |
| cg13785223 | 0.4713 | 0.4286 | 4.20E-06 | 13 | 114905788 | IGR | NA |
| cg14235800 | 0.8887 | 0.8982 | 2.01E-05 | 9 | 104238593 | C9orf125 | Body-open sea |
| cg14323199 | 0.0517 | 0.0572 | 3.99E-06 | 17 | 60705839 | MRC2 | Body-island |
| cg14416269 | 0.2198 | 0.1914 | 4.71E-06 | 4 | 6271139 | WFS1 | TSS1500-shore |
| cg14420670 | 0.0328 | 0.0382 | 8.18E-08 | 6 | 29617961 | IGR | chr6:29617765-29617974 |
| cg14951488 | 0.1623 | 0.1538 | 1.73E-05 | 10 | 95256188 | CEP55 | TSS200-island |
| cg15248835 | 0.0413 | 0.0485 | 1.76E-05 | 8 | 9761171 | LOC157627 | TSS1500-island |
| cg15354625 | 0.9302 | 0.9372 | 4.06E-06 | 11 | 78381223 | ODZ4 | Body-open sea |
| cg15404375 | 0.9397 | 0.9458 | 2.02E-05 | 4 | 111866546 | IGR | NA |
| cg15731816 | 0.0361 | 0.0408 | 6.70E-07 | 14 | 75230414 | YLPM1 | 1st Exon-island |
| cg15896939 | 0.9280 | 0.9352 | 1.35E-05 | 1 | 156030809 | RAB25 | TSS200-opensea |
| cg15935247 | 0.7404 | 0.7189 | 2.31E-06 | 17 | 56606842 | 4-Sep | TSS200-shelf |
| cg16311364 | 0.5388 | 0.4808 | 1.07E-06 | 10 | 46912902 | FAM35B | Body-shore |
| cg16374753 | 0.9620 | 0.9682 | 2.27E-06 | X | 79279642 | TBX22 | Body-open sea |
| cg16513883 | 0.8804 | 0.8923 | 2.90E-05 | 5 | 9295286 | SEMA5A | Body-open sea |
| cg16619899 | 0.8632 | 0.8492 | 6.18E-06 | 8 | 915860 | IGR | chr8:914817-915894 |
| cg16925090 | 0.0692 | 0.0790 | 4.46E-06 | 11 | 101785516 | KIAA1377 | TSS1500-shore |
| cg17098965 | 0.3396 | 0.3067 | 3.26E-07 | 20 | 52199520 | ZNF217 | 5’ UTR-shore |
| cg17329834 | 0.8211 | 0.7991 | 4.98E-06 | 6 | 131380543 | EPB41L2 | 5’ UTR-shelf |
| cg17392909 | 0.2192 | 0.2510 | 4.35E-09 | 10 | 135187035 | ECHS1 | TSS200-island |
| cg17524854 | 0.0458 | 0.0515 | 8.21E-08 | 12 | 67663046 | CAND1 | TSS200-island |
| cg18050997 | 0.8858 | 0.8970 | 6.34E-08 | 8 | 8176225 | PRAGMIN | Body-island |
| cg18483322 | 0.0772 | 0.0845 | 3.01E-06 | 2 | 97523826 | ANKRD39 | TSS200-island |
| cg18651347 | 0.8273 | 0.8092 | 2.18E-05 | 7 | 70102632 | AUTS2 | Body-open sea |
| cg18725195 | 0.6238 | 0.6550 | 5.79E-07 | 5 | 976058 | IGR | NA |
| cg18943383 | 0.0329 | 0.0402 | 6.49E-09 | 6 | 27777858 | HIST1H3H | 1st Exon-island |
| cg19239278 | 0.7810 | 0.7583 | 2.98E-06 | 19 | 19513162 | GATAD2A | 5’ UTR-shelf |
| cg19242459 | 0.9213 | 0.9302 | 1.99E-08 | 2 | 239006511 | SCLY | Body-shelf |
| cg19757631 | 0.8720 | 0.8529 | 6.65E-06 | 1 | 11118889 | SRM | Body-shore |
| cg19864851 | 0.0275 | 0.0333 | 1.48E-08 | 10 | 75503847 | SEC24C | TSS1500-shore |
| cg20153768 | 0.0334 | 0.0376 | 2.42E-05 | 6 | 26123228 | HIST1H2AC | TSS1500-shore |
| cg20390613 | 0.0432 | 0.0513 | 1.86E-07 | 1 | 12678355 | DHRS3 | TSS1500-island |
| cg20539816 | 0.9396 | 0.9334 | 4.13E-07 | 17 | 5988249 | WSCD1 | Body-open sea |
| cg21636841 | 0.8416 | 0.8540 | 1.43E-05 | 11 | 968731 | AP2A2 | Body-open sea |
| cg22028624 | 0.8741 | 0.8513 | 1.01E-07 | 11 | 70281091 | CTTN | Body-open sea |
| cg22110517 | 0.9086 | 0.9168 | 4.36E-06 | 17 | 4800583 | MINK1 | 3’ UTR-shore |
| cg22407822 | 0.6570 | 0.6790 | 7.54E-08 | 20 | 57463658 | GNAS | 3’ UTR-island |
| cg22716488 | 0.0387 | 0.0437 | 2.15E-06 | 6 | 35995431 | MAPK14 | TSS200-island |
| cg22826071 | 0.0364 | 0.0452 | 2.91E-08 | 19 | 344165 | MIER2 | Body-island |
| cg22961241 | 0.8822 | 0.8999 | 1.56E-06 | 6 | 32917502 | HLA-DMA | Body-open sea |
| cg23496597 | 0.6552 | 0.6715 | 1.23E-06 | 20 | 57463725 | GNAS | 3’ UTR-island |
| cg23983453 | 0.4253 | 0.4789 | 8.55E-06 | 5 | 92925524 | NR2F1 | Body-shore |
| cg24337701 | 0.6228 | 0.5930 | 1.87E-05 | 8 | 141275191 | TRAPPC9 | Body-open sea |
| cg24751378 | 0.7014 | 0.7205 | 2.26E-06 | 21 | 30396349 | USP16 | TSS1500-shore |
| cg25079743 | 0.0262 | 0.0311 | 7.23E-07 | 16 | 30441674 | DCTPP1 | TSS1500-island |
| cg25198967 | 0.8953 | 0.9066 | 7.74E-08 | 3 | 52325846 | GLYCTK | Body-shelf |
| cg25554036 | 0.2521 | 0.2127 | 7.34E-07 | 4 | 6271136 | WFS1 | TSS1500-shore |
| cg25696807 | 0.7097 | 0.6766 | 6.39E-07 | X | 145109374 | MIR891A | Body-open sea |
| cg25697492 | 0.1212 | 0.1110 | 1.54E-05 | 19 | 2950919 | IGR | chr19:2950359-2950962 |
| cg25748441 | 0.0329 | 0.0383 | 2.47E-05 | 2 | 202122587 | CASP8 | 5’ UTR-open sea |
| cg25806190 | 0.8185 | 0.7973 | 3.24E-06 | 2 | 232878174 | DIS3L2 | 5’ UTR-open sea |
| cg26127025 | 0.9343 | 0.9201 | 1.11E-06 | 5 | 2703138 | IGR | NA |
| cg26683137 | 0.3639 | 0.3234 | 7.98E-06 | 17 | 33447208 | FNDC8 | TSS1500-shore |
| cg27482619 | 0.0574 | 0.0663 | 7.74E-11 | 10 | 30818479 | IGR | NA |