Figure 1.

Research achievements of lncRNA alternative splicing in several investigations. A. MBNL3 increases the expression of PXN protein by inducing the inclusion of lncRNA-PXN-AS1 exon 4 in hepatocellular carcinoma (HCC) cells. B. LncHOXA10 drives the transcription initiation of HOXA10 by interacting and recruiting NURF chromatin remodeling complex to its promoter. C. UV irradiation causes a decrease in the expression of ASCC3 mRNA and an increase in the expression of ASCC3 lncRNA transcript. And the two transcripts of ASCC3 play antagonistic effects on transcriptional recovery after DNA damage.