Table 1.
LncRNAs being alternatively spliced
| LncRNA | Transcripts involved | Relationship between transcripts | Target genes or regulated genes | Other significant results | Diseases or processes | References |
|---|---|---|---|---|---|---|
| CASC18 | CASC18-A1, A2, B1, B2, C, D1, D2 | Not investigated | PAX6 | CASC18-D has potential of being a neural cell differentiation marker | Neural differentiation | [44] |
| CRNDE | CRNDE-a, b, c, d, e, f, g, h, i, j, k, l | Not investigated | Not investigated | CRNDE-g is the most expressed transcript in various cancer types | Various solid and hematopoietic malignancies | [71] |
| LHFPL3-AS1 | LHFPL3-AS1-long and LHFPL3-AS1-short | Not investigated | miR-181a-5p and Bcl-2 | PTBP1 mediates the alternative splicing of lncRNA LHFPL3-AS1 precursor towards LHFPL3-AS1-long transcript | Melanoma | [73] |
| PCAT19 | PCAT19-long and PCAT19-short | reciprocal expression and clinical relevance | HNRNPAB and a subset of cell-cycle genes | rs11672691 increases PCAT19-long and decreases PCAT19-short by mediating promoter-enhancer switching | Prostate cancer | [74] |
| PVT1 | Pvt1a and Pvt1b | Opposite roles in the regulation of Myc | Myc | Pvt1b is induced by p53-mediated response to stress | Lung cancer | [75] |
| Full-length transcript and transcript lacking exon 4 (PVT1ΔE4) | Similar roles in the proliferation of tumor cells and sponging miR-200s | miR-200s | SRSF1 up-regulates the expression of PVT1ΔE4 | Clear cell renal cell carcinoma | [85] | |
| linc00320 | linc00320-002, 006, 007 | Not investigated | Not investigated | linc00320-002 is highly expressed in the white matter compared to grey matter in the multiple system atrophy brain and normal brain | Multiple system atrophy | [76] |
| H19 | H19 variant lacking part of exon 1 | Not investigated | Not investigated | H19 variant lacking part of exon 1 is expressed in embryonic and placental not cancer issues | Embryonic and placental development | [77] |
| CASC2 | CASC2a/b and CASC2c | Similar roles in the proliferation of tumor cells | miR-18a, JNK, ERK1/2, β-catenin | None | Hepatocellular carcinoma, gastric cancer and colorectal cancer | [78-80] |
| LINC00477 | LINC00477 isoform 1, 2 and 3 | Opposite roles in the cell proliferation and migration | ACO1 | Isoform 1 suppresses the conversion ability from citrate to isocitrate by binding to ACO1 | Gastric cancer | [86] |
| PXN-AS1 | PXN-AS1-L and PXN-AS1-S | Opposite roles in the regulation of PXN and tumor development | PXN | MBNL3 increases PXN expression by inducing lncRNA-PXN-AS1 exon 4 inclusion | Hepatocellular carcinoma | [87] |
| MALAT1 | FL-MALAT1 and Δsv-MALAT1 | Unique role for each transcript | Genes involved in the PI3K/AKT pathway | The expression of Δsv-MALAT1 is likely to be regulated by YAP | Breast cancer | [93] |
| GAS5 | Full-Length (FL) and Clone 2 (C2) | Unique role for each transcript | P53, BRCA1, GADD45A | FL rescues cell cycle arrest, while C2 enhances cell apoptosis | Neuroblastoma | [94] |
| MIR503HG | at least four distinct transcripts in human placenta and multiple transcripts in other tissues | Not investigated | Not investigated | MIR503HG transcripts are downregulated in gynecological cancers | Gynecological cancers | [104] |