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. 2021 Mar 1;11(3):849–857.

Table 2.

Relationship between polymorphisms in base excision repair pathway genes and hepatoblastoma susceptibility in Chinese children

Gene Polymorphism Allele Cases Controls AOR (95% CI)a P a AOR (95% CI)b P b
W M WW WM MM WW WM MM
PARP1 rs1136410 A G 101 157 49 501 665 279 1.08 (0.83-1.40) 0.561 0.79 (0.56-1.10) 0.157
PARP1 rs2666428 T C 185 111 11 911 492 42 1.12 (0.87-1.45) 0.365 1.22 (0.62-2.41) 0.560
PARP1 rs8679 A G 272 33 2 1279 162 4 0.99 (0.67-1.46) 0.971 2.38 (0.43-13.07) 0.318
hOGG1 rs1052133 G C 103 153 55 449 749 247 0.91 (0.70-1.18) 0.484 1.05 (0.76-1.44) 0.789
hOGG1 rs159153 T C 254 52 5 1139 292 14 0.84 (0.61-1.14) 0.263 1.68 (0.60-4.71) 0.323
hOGG1 rs293795 A G 273 34 4 1289 151 5 1.14 (0.78-1.67) 0.492 3.78 (1.01-14.17) 0.049
FEN1 rs174538 A G 95 142 76 491 635 319 1.18 (0.90-1.53) 0.230 1.13 (0.85-1.51) 0.402
FEN1 rs4246215 T G 94 142 77 490 641 314 1.19 (0.91-1.55) 0.198 1.17 (0.88-1.56) 0.271
APEX1 rs1130409 T G 111 147 54 481 704 260 0.90 (0.70-1.16) 0.416 0.96 (0.69-1.32) 0.784
APEX1 rs1760944 T G 110 156 46 487 687 271 0.93 (0.72-1.20) 0.582 0.75 (0.53-1.05) 0.097
APEX1 rs3136817 T C 251 57 4 1176 253 16 1.06 (0.78-1.45) 0.701 1.18 (0.39-3.55) 0.773
LIG3 rs1052536 C T 147 127 36 680 634 132 0.98 (0.77-1.26) 0.897 1.31 (0.88-1.93) 0.182
LIG3 rs3744356 C T 301 7 2 1398 48 0 0.88 (0.43-1.81) 0.729 / /
LIG3 rs4796030 A C 92 142 76 426 720 300 0.99 (0.75-1.29) 0.922 1.25 (0.93-1.66) 0.137
XRCC1 rs1799782 G A 143 140 27 710 611 125 1.13 (0.88-1.44) 0.347 1.00 (0.65-1.55) 0.997
XRCC1 rs25487 C T 169 116 25 803 529 114 1.04 (0.82-1.34) 0.732 1.02 (0.65-1.60) 0.939
XRCC1 rs25489 C T 253 51 6 1169 250 27 0.95 (0.69-1.30) 0.753 1.07 (0.44-2.62) 0.886
XRCC1 rs2682585 G A 234 69 7 1126 292 28 1.15 (0.87-1.54) 0.328 1.19 (0.52-2.76) 0.681
XRCC1 rs3810378 G C 165 122 23 777 541 128 1.02 (0.80-1.30) 0.878 0.82 (0.51-1.30) 0.387
XRCC1 rs915927 T C 236 72 2 1125 297 24 1.11 (0.83-1.49) 0.470 0.39 (0.09-1.65) 0.200

AOR, adjusted odds ratio; CI, confidence interval, HWE, Hardy-Weinberg equilibrium.

a

Adjusted for age and sex for dominant model (MM/WM vs. WW).

b

Adjusted for age and sex for recessive model (MM vs. WW/WM).