Table 4.
False-positive report probability analysis for significant findings
| Genotype | OR (95% CI) | P a | Statistical powerb | Prior probability | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| 0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
| rs293795 A>G | ||||||||
| GG vs. AA/GA | 3.752 (1.002-14.055) | 0.0497 | 0.092 | 0.619 | 0.830 | 0.982 | 0.998 | 1.000 |
| Stage I/II | 5.503 (1.303-23.246) | 0.0204 | 0.046 | 0.570 | 0.799 | 0.978 | 0.998 | 1.000 |
| rs159153 TC/CC vs. TT | ||||||||
| Male | 0.604 (0.392-0.931) | 0.0223 | 0.330 | 0.169 | 0.378 | 0.870 | 0.985 | 0.999 |
| Risk genotypes 1-3 vs. 0 | ||||||||
| Male | 1.379 (1.000-1.900) | 0.0497 | 0.699 | 0.176 | 0.390 | 0.876 | 0.986 | 0.999 |
OR, odds ratio; CI, confidence interval.
a
Chi-square test was used to calculate the genotype frequency distributions.
b
Statistical power was calculated using the number of observations in each subgroup and the corresponding ORs and P values in this table.